Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Department of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada.
Sci Data. 2022 May 27;9(1):238. doi: 10.1038/s41597-022-01341-2.
Magnetic resonance image (MRI) processing pipelines use average templates to enable standardization of individual MRIs in a common space. MNI-ICBM152 is currently used as the standard template by most MRI processing tools. However, MNI-ICBM152 represents an average of 152 healthy young adult brains and is vastly different from brains of patients with neurodegenerative diseases. In those populations, extensive atrophy might cause inevitable registration errors when using an average template of young healthy individuals for standardization. Disease-specific templates that represent the anatomical characteristics of the populations can reduce such errors and improve downstream driven estimates. We present multi-sequence average templates for Alzheimer's Dementia (AD), Fronto-temporal Dementia (FTD), Lewy Body Dementia (LBD), Mild Cognitive Impairment (MCI), cognitively intact and impaired Parkinson's Disease patients (PD-CIE and PD-CI, respectively), individuals with Subjective Cognitive Impairment (SCI), AD with vascular contribution (V-AD), Vascular Mild Cognitive Impairment (V-MCI), Cognitively Intact Elderly (CIE) individuals, and a human phantom. We also provide separate templates for males and females to allow better representation of the diseases in each sex group.
磁共振成像 (MRI) 处理管道使用平均模板在公共空间中实现个体 MRI 的标准化。大多数 MRI 处理工具目前都将 MNI-ICBM152 用作标准模板。然而，MNI-ICBM152 代表了 152 名健康年轻成年人的平均水平，与患有神经退行性疾病的患者的大脑有很大的不同。在这些人群中，当使用年轻健康个体的平均模板进行标准化时，广泛的萎缩可能会导致不可避免的配准错误。代表人群解剖特征的特定于疾病的模板可以减少这些错误并改善下游驱动的估计。我们为阿尔茨海默病 (AD)、额颞叶痴呆 (FTD)、路易体痴呆 (LBD)、轻度认知障碍 (MCI)、认知正常和受损的帕金森病患者 (PD-CIE 和 PD-CI)、有主观认知障碍的个体 (SCI)、有血管贡献的 AD (V-AD)、血管性轻度认知障碍 (V-MCI)、认知正常的老年人 (CIE) 以及人体模型提供了多序列平均模板。我们还为男性和女性提供了单独的模板，以更好地代表每个性别组中的疾病。
