E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
Bull Exp Biol Med. 2022 May;173(1):17-20. doi: 10.1007/s10517-022-05483-6. Epub 2022 May 28.
The effect of p-tyrosol on the main hemodynamic parameters and contractile function of the heart was studied and a morphometric assessment of left-ventricular remodeling was performed in Wistar rats 2 months after acute 1-h myocardial ischemia followed by reperfusion. p-Tyrosol in a dose of 20 mg/kg was injected intraperitoneally 5 times: 20 min before the start of reperfusion, 4 h after the start of reperfusion, and then once a day over the next 3 days. Administration of p-tyrosol to animals in the acute period of myocardial infarction slowed down the formation of systolic and diastolic myocardial dysfunction, improved the pumping function of the heart, maintained the hemodynamic parameters at a significantly higher level, and reduced left-ventricular remodeling in the late period of myocardial infarction. In 2 months after acute myocardial ischemia modeling, the dimensions of the left-ventricular cavity, the area of the postinfarction focus, and the area of connective tissue in rats treated with p-tyrosol were significantly lower than in the control group. In the group treated with p-tyrosol, no anterior left-ventricular wall aneurysms were found.
研究了对羟基苯乙醇对主要血流动力学参数和心脏收缩功能的影响，并在急性 1 小时心肌缺血后继发再灌注后 2 个月对 Wistar 大鼠进行了左心室重构的形态计量评估。对羟基苯乙醇以 20mg/kg 的剂量腹腔内注射 5 次：再灌注开始前 20 分钟、再灌注开始后 4 小时，然后在接下来的 3 天内每天一次。在心肌梗死的急性期给予动物对羟基苯乙醇可减缓收缩和舒张性心肌功能障碍的形成，改善心脏的泵血功能，使血流动力学参数保持在显著更高的水平，并减少心肌梗死后的左心室重构。在急性心肌缺血模型建立 2 个月后，与对照组相比，用对羟基苯乙醇治疗的大鼠的左心室腔尺寸、梗死后病灶面积和结缔组织面积明显降低。在用对羟基苯乙醇治疗的组中，未发现前壁左心室壁动脉瘤。
