Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
ESC Heart Fail. 2022 Aug;9(4):2645-2653. doi: 10.1002/ehf2.13989. Epub 2022 May 27.
To explore the associations between serum phenylacetylglutamine (PAGln) and chronic heart failure (HF).
Totally 956 subjects were enrolled consecutively from the Department of Cardiovascular Medicine, Ruijin Hospital. Baseline data were obtained from all participants, and 471 stable chronic HF subjects were followed up. Serum PAGln was analysed by liquid chromatography-tandem mass spectrometry. The association between PAGln and basic renal indicators was assessed by simple correlation analysis. Logistic regression analysis was conducted to measure the association between PAGln and HF risk. Event-free survival was determined by Kaplan-Meier curves, and differences in survival were assessed using log-rank tests. Cox proportional hazards analysis was used to assess the prognostic value of PAGln in HF. Serum PAGln levels were increased in patients with chronic HF (3.322 ± 8.220 μM vs. 1.249 ± 1.168 μM, P < 0.001) and were associated with HF after full adjustment [odds ratio (OR), 1.507; 95% confidence interval (CI): 1.213-1.873; P < 0.001]. PAGln levels were correlated with the levels of basic renal indicators. High PAGln levels indicated a high risk of renal dysfunction in HF (OR: 1.853; 95% CI: 1.344-2.556; P < 0.001), and elevated PAGln levels were associated with a high risk of cardiovascular death in patients with chronic HF (HR: 2.049; 95% CI: 1.042-4.029; P = 0.038).
Elevated PAGln levels are an independent risk factor for HF and are associated with a higher risk of cardiovascular death. High PAGln levels could indicate renal dysfunction in HF patients. PAGln can be a valuable indicator of HF.
探讨血清苯乙酰谷氨酰胺（PAGln）与慢性心力衰竭（HF）的关系。
连续纳入瑞金医院心血管内科的 956 名受试者。所有参与者均获得基线数据，其中 471 例稳定慢性 HF 患者进行了随访。采用液相色谱-串联质谱法分析血清 PAGln。采用简单相关分析评估 PAGln 与基本肾功能指标的相关性。采用 logistic 回归分析测量 PAGln 与 HF 风险的关系。通过 Kaplan-Meier 曲线确定无事件生存率，并通过对数秩检验评估生存率差异。Cox 比例风险分析用于评估 PAGln 在 HF 中的预后价值。慢性 HF 患者的血清 PAGln 水平升高（3.322±8.220 μM 比 1.249±1.168 μM，P<0.001），且在充分调整后与 HF 相关[比值比（OR），1.507；95%置信区间（CI）：1.213-1.873；P<0.001]。PAGln 水平与基本肾功能指标水平相关。高 PAGln 水平提示 HF 患者肾功能障碍风险较高（OR：1.853；95%CI：1.344-2.556；P<0.001），且升高的 PAGln 水平与慢性 HF 患者心血管死亡风险较高相关（HR：2.049；95%CI：1.042-4.029；P=0.038）。
升高的 PAGln 水平是 HF 的独立危险因素，与心血管死亡风险增加相关。HF 患者 PAGln 水平升高可能提示肾功能障碍。PAGln 可能是 HF 的一个有价值的指标。
