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基于 C 反应蛋白的即时检测诊断。

Diagnoses Based on C-Reactive Protein Point-of-Care Tests.

机构信息

Faculty of Military Health Sciences, University of Defense, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic.

出版信息

Biosensors (Basel). 2022 May 17;12(5):344. doi: 10.3390/bios12050344.

Abstract

C-reactive protein (CRP) is an important part of the immune system's reaction to various pathological impulses such as bacterial infections, systemic inflammation, and internal organ failures. An increased CRP level serves to diagnose the mentioned pathological states. Both standard laboratory methods and simple point-of-care devices such as lateral flow tests and immunoturbidimetric assays serve for the instrumental diagnoses based on CRP. The current method for CRP has many flaws and limitations in its use. Biosensor and bioassay analytical devices are presently researched by many teams to provide more sensitive and better-suited tools for point-of-care tests of CRP in biological samples when compared to the standard methods. This review article is focused on mapping the diagnostical relevance of CRP, the applicability of the current analytical methods, and the recent innovations in the measurement of CRP level.

摘要

C 反应蛋白(CRP)是免疫系统对各种病理刺激(如细菌感染、全身炎症和内脏器官衰竭)反应的重要组成部分。CRP 水平升高有助于诊断上述病理状态。基于 CRP 的仪器诊断既可以使用标准实验室方法,也可以使用侧向流动检测和免疫比浊测定等简单的即时检测设备。目前的 CRP 检测方法在使用上存在诸多缺陷和限制。与标准方法相比,生物传感器和生物分析检测设备目前正被许多团队研究,以期为生物样本的 CRP 即时检测提供更灵敏、更适用的工具。本文综述了 CRP 的诊断相关性、当前分析方法的适用性以及 CRP 水平测量的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cce/9138282/2b44a9ae7af3/biosensors-12-00344-g001.jpg

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