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罕见的黏液样软骨肉瘤伴胰腺转移病例报告。

A Rare Case Report of Mesenchymal Chondrosarcoma with Pancreatic Metastasis.

机构信息

Division of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404333, Taiwan.

出版信息

Medicina (Kaunas). 2022 May 5;58(5):639. doi: 10.3390/medicina58050639.

DOI:10.3390/medicina58050639
PMID:35630056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9144319/
Abstract

: Mesenchymal chondrosarcoma is a rare but aggressive subtype of sarcoma. The majority of involvement locates in the axial skeleton. Treatment modalities include radical surgery, local radiotherapy, and systemic chemotherapy. However, the long-term survival outcome remains poor. : We present the case of a 33-year-old male with a palpable chest wall mass for one year, diagnosed with mesenchymal chondrosarcoma with surgical removal. Later, he had an unusual pancreatic tail tumor as the first presentation of disease metastasis which was proven by surgical resection one year later. : Although mesenchymal chondrosarcoma locates mainly in the axial skeletal system, extra-skeletal soft tissue or organ involvement might be seen occasionally. Active surveillance with multidisciplinary team management could significantly prolong survival outcomes.

摘要

: 间叶性软骨肉瘤是一种罕见但具有侵袭性的肉瘤亚型。大多数病变位于中轴骨骼。治疗方式包括根治性手术、局部放疗和全身化疗。然而,长期生存结果仍然不佳。: 我们报告了 1 例 33 岁男性,1 年前出现可触及的胸壁肿块,诊断为间叶性软骨肉瘤,行手术切除。1 年后,他首次出现胰腺尾部肿瘤作为疾病转移的表现,经手术切除证实。: 尽管间叶性软骨肉瘤主要位于中轴骨骼系统,但偶尔也会出现骨骼外软组织或器官受累。多学科团队管理的积极监测可以显著延长生存结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930f/9144319/65b91a5da232/medicina-58-00639-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930f/9144319/512a397ffe0a/medicina-58-00639-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930f/9144319/65b91a5da232/medicina-58-00639-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930f/9144319/512a397ffe0a/medicina-58-00639-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930f/9144319/65b91a5da232/medicina-58-00639-g002.jpg

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NKX3.1 a useful marker for mesenchymal chondrosarcoma: An immunohistochemical study.NKX3.1:间叶性软骨肉瘤的一种有用标志物——一项免疫组织化学研究
Ann Diagn Pathol. 2021 Feb;50:151660. doi: 10.1016/j.anndiagpath.2020.151660. Epub 2020 Nov 5.
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Medicina (Kaunas). 2023 Feb 24;59(3):454. doi: 10.3390/medicina59030454.
《2020 年世卫组织软组织肿瘤分类:精选变更和新实体》。
Adv Anat Pathol. 2021 Jan;28(1):44-58. doi: 10.1097/PAP.0000000000000284.
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