Nutrigenomics Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nutrients. 2022 May 13;14(10):2047. doi: 10.3390/nu14102047.
Consuming (poly)phenol-rich fruits and vegetables, including tomato, is associated with health benefits. The health effects of tomato (poly)phenolic compounds have been attributed to their metabolites rather than parent compounds and their bioavailability can be modulated by several factors. This study aimed to evaluate the effect of seasonal consumption of local tomatoes on their (poly)phenol bioavailability. For this, (poly)phenol absorption and metabolism were evaluated by ultra-high-performance liquid chromatography coupled with mass spectrometry and linear ion trap mass spectrometric (uHPLC-MS) after chronic tomato consumption in Fischer rats exposed to three photoperiods mimicking the seasonal daylight schedule. Tomatoes from two locations in Spain (LT, local tomatoes and NLT, non-local tomatoes) were used in this in vivo feeding study. The bioavailability of tomato (poly)phenols depended on the photoperiod to which the rats were exposed, the metabolite concentrations significantly varying between seasons. In-season tomato consumption allowed obtaining the highest concentration of total circulating metabolites. In addition, the origin of the tomato administered generated marked differences in the metabolic profiles, with higher serum concentrations reached upon NLT ingestion. We concluded that in-season tomato consumption led to an increase in (poly)phenol circulation, whereas LT consumption showed lower circulating metabolites than NLT ones. Thus, the origin of the tomato and the seasonal daylight schedule affect the bioavailability of tomato (poly)phenols, which could also affect their bioactivity.
食用富含（多）酚的水果和蔬菜，包括番茄，与健康益处有关。番茄（多）酚类化合物的健康影响归因于它们的代谢物而不是母体化合物，并且它们的生物利用度可以通过多种因素来调节。本研究旨在评估季节性食用当地番茄对其（多）酚生物利用度的影响。为此，在暴露于模拟季节性日光时间表的三种光周期的 Fischer 大鼠中进行慢性番茄消费后，通过超高效液相色谱-串联质谱法（uHPLC-MS）和线性离子阱质谱（LIT-MS）评估（多）酚的吸收和代谢。在这项体内喂养研究中，使用了来自西班牙两个地点的番茄（LT，当地番茄和 NLT，非当地番茄）。番茄（多）酚的生物利用度取决于大鼠暴露的光周期，代谢物浓度在季节之间有显著差异。当季食用番茄可获得最高浓度的总循环代谢物。此外，所给予的番茄的来源在代谢谱中产生了明显的差异，NLT 摄入时血清浓度更高。我们得出结论，当季食用番茄可增加（多）酚的循环，而 LT 消费的循环代谢物低于 NLT。因此，番茄的来源和季节性日光时间表会影响番茄（多）酚的生物利用度，这也可能影响其生物活性。
