赖氨酸-赖氨酸二肽对哺乳仔猪血清氨基酸谱、肠道形态和微生物群的影响
Effects of Lysine-Lysine Dipeptide on Serum Amino Acid Profiles, Intestinal Morphology, and Microbiome in Suckling Piglets.
作者信息
Deng Yuankun, Han Hui, He Liuqin, Deng Dun, Wang Jing, Yin Yulong, Li Tiejun
机构信息
College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Hunan Provincial Engineering Research Centre for Healthy Livestock and Poultry Production, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.
出版信息
Front Nutr. 2022 May 10;9:881371. doi: 10.3389/fnut.2022.881371. eCollection 2022.
AIMS
Small peptides are more energy-saving and efficiently absorbed compared to amino acids. Our study aimed to evaluate the effect of the Lys-Lys dipeptide on the improvement of growth performance, amino acid metabolism, and gut development in suckling piglets.
METHODS AND RESULTS
Twenty-eight newborn suckling piglets were orally administrated with 0.1%, 1%, and 5% Lys-Lys dipeptide for 21 days. Our results showed that the Lys-Lys dipeptide has no significant effect on growth performance and intestinal morphology compared with the control group. We also found that the 1% Lys-Lys dipeptide significantly increased the concentrations of serum Lys, Thr, Phe, and Pro while decreasing Cys compared to the control group. Similarly, the 5% Lys-Lys dipeptide markedly increased the concentrations of serum Lys, Iso, Thr, Asp, Glu, and Pro compared to the control group. Moreover, the Lys-Lys dipeptide downregulated the expression of jejunal , and and ileal . Additionally, the Lys-Lys dipeptide decreased the microbiota richness indices and relative abundance of .
CONCLUSION
In this study, we found that the Lys-Lys dipeptide contributes to the metabolism of amino acids but failed to affect the growth performance of piglets. Additionally, the Lys-Lys dipeptide decreased the relative abundance of . These results provide a theoretical for the future application and research of Lys-Lys dipeptide in intestinal development of suckling piglets.
目的
与氨基酸相比，小肽更节能且吸收效率更高。我们的研究旨在评估赖氨酸-赖氨酸二肽对哺乳仔猪生长性能、氨基酸代谢和肠道发育改善的影响。
方法与结果
28头新生哺乳仔猪分别口服0.1%、1%和5%的赖氨酸-赖氨酸二肽，持续21天。我们的结果表明，与对照组相比，赖氨酸-赖氨酸二肽对生长性能和肠道形态没有显著影响。我们还发现，与对照组相比，1%的赖氨酸-赖氨酸二肽显著提高了血清赖氨酸、苏氨酸、苯丙氨酸和脯氨酸的浓度，同时降低了半胱氨酸的浓度。同样，与对照组相比，5%的赖氨酸-赖氨酸二肽显著提高了血清赖氨酸、异亮氨酸、苏氨酸、天冬氨酸、谷氨酸和脯氨酸的浓度。此外，赖氨酸-赖氨酸二肽下调了空肠和回肠的表达。另外，赖氨酸-赖氨酸二肽降低了微生物群丰富度指数和的相对丰度。
结论
在本研究中，我们发现赖氨酸-赖氨酸二肽有助于氨基酸代谢，但未能影响仔猪的生长性能。此外，赖氨酸-赖氨酸二肽降低了的相对丰度。这些结果为赖氨酸-赖氨酸二肽在哺乳仔猪肠道发育中的未来应用和研究提供了理论依据。
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