Allison Karen, Patel Deepkumar, Kaur Ramandeep
Department of Ophthalmology, Mount Sinai Hospital, New York, USA.
Public Health, New York Medical College, School of Health Science and Practice, Valhalla, USA.
Cureus. 2022 Apr 23;14(4):e24424. doi: 10.7759/cureus.24424. eCollection 2022 Apr.
The purpose of this review is to analyze factors that influence individuals' decisions to participate in clinical trials focusing on racial and ethnic disparities that exist in clinical trials. These factors are then used to develop a survey that may be used in a clinical setting to further understand specific factors affecting participation. A comprehensive search of electronic databases was carried out for publications from 2010 to 2021 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After reviewing the data, the predominant factors that were encountered in the search were then commented upon and reviewed to create an evidence-based questionnaire. Using the comprehensive search, factors that affect clinical trial participation were identified. These factors were then used to create a comprehensive, evidence-based questionnaire to be implemented in a clinical setting to conduct and analyze the factors impacting participation in clinical trials. Understanding the factors that primarily impact an individual's decisions to participate or not participate in a clinical trial allow researchers to implement changes to decrease the hesitancy regarding participation.
本综述的目的是分析影响个人参与临床试验决策的因素，重点关注临床试验中存在的种族和族裔差异。然后利用这些因素设计一项调查，可在临床环境中使用，以进一步了解影响参与的具体因素。使用系统评价和Meta分析的首选报告项目（PRISMA）指南，对2010年至2021年的电子数据库进行了全面检索。在审查数据后，对检索中遇到的主要因素进行了评论和审查，以创建一份基于证据的问卷。通过全面检索，确定了影响临床试验参与的因素。然后利用这些因素创建一份全面的、基于证据的问卷，在临床环境中实施，以调查和分析影响参与临床试验的因素。了解主要影响个人参与或不参与临床试验决策的因素，有助于研究人员做出改变，以减少对参与的犹豫。
