小胶质细胞介导的神经炎症：心血管疾病治疗的潜在靶点。
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases.
作者信息
Wang Menglong, Pan Wei, Xu Yao, Zhang Jishou, Wan Jun, Jiang Hong
机构信息
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China.
Cardiovascular Research Institute, Wuhan University, Wuhan, 430060, People's Republic of China.
出版信息
J Inflamm Res. 2022 May 25;15:3083-3094. doi: 10.2147/JIR.S350109. eCollection 2022.
Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases.
小胶质细胞是中枢神经系统（CNS）的组织驻留巨噬细胞。在中枢神经系统中，小胶质细胞在监测和干预突触及神经元水平的活动中发挥着重要作用。针对小胶质细胞的干预已被证明可改善各种神经系统疾病的预后。最近，研究观察到不同心血管疾病中存在小胶质细胞的激活。此外，调节小胶质细胞活性的不同方法已被证明可调节心血管疾病的发生和发展。神经炎症后自主神经系统活动的变化可能是小胶质细胞与心血管疾病之间潜在的中间环节。在此综述中，我们将讨论小胶质细胞在高血压、心肌梗死和缺血/再灌注损伤中的调节作用的最新进展。我们提出小胶质细胞作为神经免疫调节剂以及心血管疾病的潜在靶点。
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