State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China, 200438; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, PR China, 200438.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA.
Trends Parasitol. 2022 Aug;38(8):697-708. doi: 10.1016/j.pt.2022.05.002. Epub 2022 May 26.
Disease-transmitting vectors are living organisms that pass infectious agents from one animal/human to another. The epidemiologically important vectors are usually hematophagous arthropods, including mosquitoes, ticks, triatome bugs, sand flies, and tsetse flies. All of them harbor an endogenous microbiota that functionally complements their host's biology. Different arthropod vectors are ecologically and behaviorally distinct, and as such, their relationships with symbiotic microbes vary. In this review, we summarize the recent discoveries that reveal how bacterial metabolic activities influence development, nutrition, and pathogen defense in mosquitoes, ticks, triatome bugs, and sand flies. These studies provide a foundation for a systematic understanding of vector-microbiota interactions and for the development of integrated approaches to control vector-borne diseases.
病媒传播者是指将传染病原体从一种动物/人类传播到另一种动物/人类的活体生物。在流行病学上重要的病媒通常是吸血节肢动物，包括蚊子、蜱、三锥虫、沙蝇和采采蝇。它们都携带着功能上补充宿主生物学的内共生微生物群。不同的节肢动物病媒在生态和行为上有很大的不同，因此它们与共生微生物的关系也不同。在这篇综述中，我们总结了最近的发现，这些发现揭示了细菌代谢活动如何影响蚊子、蜱、三锥虫和沙蝇的发育、营养和病原体防御。这些研究为系统了解媒介-微生物相互作用以及开发综合方法来控制媒介传播疾病奠定了基础。
