Wang Zhe, Zhao Yili, Shen Mingwu, Tomás Helena, Zhou Benqing, Shi Xiangyang
Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, China.
Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
J Funct Biomater. 2022 May 10;13(2):55. doi: 10.3390/jfb13020055.
Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT/DOX/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT/DOX/PLGA nanofibers, the designed organic-inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications.
目前，癌症化疗药物仍然存在毒性高和生物利用度低的缺陷，因此设计新型药物释放系统用于癌症化疗至关重要。在此，我们报道了一种制备用于抗肿瘤治疗应用的电纺载药有机/无机杂化纳米纤维系统的方法。在这项工作中，棒状凹凸棒石（ATT）被用于负载模型抗癌药物阿霉素（DOX），并与聚乳酸-乙醇酸共聚物（PLGA）混合以形成电纺杂化纳米纤维。通过各种技术对ATT/DOX/PLGA复合纳米纤维进行了表征。将DOX负载到ATT表面是可行的，并且ATT/DOX/PLGA纳米纤维呈现出光滑均匀的形态，机械耐久性得到提高。在中性和酸性pH条件下，负载的DOX从ATT/DOX/PLGA纳米纤维中持续释放。此外，从纳米纤维中释放的DOX能够显著抑制肿瘤细胞的生长。由于ATT/DOX/PLGA纳米纤维的突释曲线显著降低且机械耐久性提高，所设计的有机-无机杂化纳米纤维作为一种纳米平台，用于封装不同药物以增强局部肿瘤治疗应用可能具有巨大潜力。
