Nan Fang, Sun Yutong, Liang Hantian, Zhou Jingyang, Ma Xiao, Zhang Dunfang
Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Front Pharmacol. 2022 May 13;13:877543. doi: 10.3389/fphar.2022.877543. eCollection 2022.
As a natural sugar, mannose is a type of hexose that is abundant in many different types of fruits. Since mannose is rarely used for glycolysis in mammals, studies on the role of mannose have not attracted much attention. Glycosylation of specific proteins was thought to be the major function of mannose. Surprisingly, during the past few years, mannose was found to be effective in promoting immune tolerance and suppressing inflammatory diseases related to autoimmunity and allergy. Moreover importantly, mannose was also found to be efficient in suppressing tumors by suppressing glycolysis and enhancing chemotherapeutic agents. In this review, we summarize the recent studies of mannose on antitumor properties and anti-inflammatory characteristics. We emphasize that mannose could play a beneficial role in the treatment of a variety of diseases, including cancers and inflammatory diseases, and could be a novel therapeutic strategy that deserves continued evaluation.
作为一种天然糖，甘露糖是一种己糖，在许多不同种类的水果中含量丰富。由于甘露糖在哺乳动物中很少用于糖酵解，因此关于甘露糖作用的研究并未引起太多关注。特定蛋白质的糖基化被认为是甘露糖的主要功能。令人惊讶的是，在过去几年中，发现甘露糖在促进免疫耐受和抑制与自身免疫和过敏相关的炎症性疾病方面有效。更重要的是，还发现甘露糖通过抑制糖酵解和增强化疗药物来有效抑制肿瘤。在这篇综述中，我们总结了甘露糖在抗肿瘤特性和抗炎特性方面的最新研究。我们强调，甘露糖在包括癌症和炎症性疾病在内的多种疾病的治疗中可能发挥有益作用，并且可能是一种值得持续评估的新型治疗策略。
