Li Lihua, Zhang Jifan, Lin Yang, Zhang Yongfeng, Li Shujie, Liu Yanzhen, Zhang Yingxu, Shi Leilei, Yuan Shouzhang, Guo Lihao
NORINCO Kunming Institute of Physics, Kunming, China.
The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Front Bioeng Biotechnol. 2022 May 13;10:902312. doi: 10.3389/fbioe.2022.902312. eCollection 2022.
Using photothermal therapy to treat cancer has become an effective method, and the design of photothermal agents determines their performance. However, due to the major radiative recombination of a photogenerated electron in photothermal materials, the photothermal performance is weak which hinders their applications. In order to solve this issue, preventing radiative recombination and accelerating nonradiative recombination, which can generate heat, has been proved as a reasonable way. We demonstrated a CuMoS@MXene nanocomposite with an obviously enhanced photothermal conversion efficiency ( = 87.98%), and this improvement can be attributed to the electron migration. Then, a mechanism is proposed based on the electron transfer regulatory effect and the localized surface plasmon resonance effect, which synergistically promote nonradiative recombination and generate more heat. Overall, our design strategy shows a way to improve the photothermal performance of CuMoS, and this method can be extended to other photothermal agents to let them be more efficient in treating cancer.
利用光热疗法治疗癌症已成为一种有效的方法，光热剂的设计决定了它们的性能。然而，由于光热材料中光生电子的主要辐射复合，光热性能较弱，这阻碍了它们的应用。为了解决这个问题，防止辐射复合并加速能产生热量的非辐射复合已被证明是一种合理的方法。我们展示了一种光热转换效率明显提高（ = 87.98%）的CuMoS@MXene纳米复合材料，这种提高可归因于电子迁移。然后，基于电子转移调节效应和局域表面等离子体共振效应提出了一种机制，这两种效应协同促进非辐射复合并产生更多热量。总体而言，我们的设计策略展示了一种提高CuMoS光热性能的方法，并且这种方法可以扩展到其他光热剂，使它们在治疗癌症方面更有效。
