Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Medical Science, Edo University Iyamho, Edo State, Nigeria.
Medical Microbiology Division, Medical Laboratory Services, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria.
J Prev Med Hyg. 2022 Apr 26;63(1):E109-E114. doi: 10.15167/2421-4248/jpmh2022.63.1.1967. eCollection 2022 Mar.
Several diseases are reported to be associated with ABO/Rh blood groups. Data on the association between ABO and Rh D blood group antigens in the Nigerian population is sparse. This study aimed at determining the prevalence of Hepatitis B Virus (HBV) infection as well as its association with ABO and Rh D antigens among young Nigerian adults.
Whole blood was collected from 496 students and screened for the presence of HBsAg using an immuno-chromatographic technique. The ABO and Rh D antigen status of participants were also determined using standard techniques.
In this study, the prevalence of HBV infection was 10/496 (2.10%). Of all factors assessed, only age of participants was identified as a risk factor (P < 0.05) for HBV seropositivity. Over half 257/496 (51.5%) of subjects were of the blood group O type, while 18/496 (3.6%) were of the AB blood type which was the least in occurrence. Rh D negative blood group was observed among 24/496 (4.8%) subjects. Those with the B blood type were observed to have an insignificantly (P > 0.05) higher prevalence of HBV infection. However, with respect to Rh D antigen alone, participants negative for the antigen were observed to have a five times higher risk of acquiring HBV infection than those positive for it (OR = 5.273, 95% CI = 1.056, 26.321, P > 0.05). Combining the ABO and Rh blood group systems, an association (OR = 20.174; P > 0.05) was found to exist between B Rh D negative status and HBV infection.
Possession of B antigen without Rh D antigen is associated with increased risk of acquiring HBV infection.
有几种疾病与 ABO/Rh 血型有关。关于尼日利亚人群中 ABO 和 RhD 血型抗原之间的关联，数据很少。本研究旨在确定乙型肝炎病毒 (HBV) 感染的流行情况，以及其与年轻尼日利亚成年人 ABO 和 RhD 抗原之间的关系。
从 496 名学生中采集全血，使用免疫层析技术检测 HBsAg 的存在。还使用标准技术确定参与者的 ABO 和 RhD 抗原状态。
在这项研究中，HBV 感染的患病率为 10/496（2.10%）。在所评估的所有因素中，只有参与者的年龄被确定为 HBV 血清阳性的危险因素（P < 0.05）。在所有受试者中，超过一半（51.5%）为 O 型血，而 AB 型血（最不常见）为 18/496（3.6%）。在 496 名受试者中，有 24/496（4.8%）为 RhD 阴性血型。观察到 B 型血的人 HBV 感染的患病率略有升高（P > 0.05）。然而，就 RhD 抗原而言，抗原阴性的参与者感染 HBV 的风险比抗原阳性的参与者高五倍（OR = 5.273，95%CI = 1.056，26.321，P > 0.05）。结合 ABO 和 Rh 血型系统，发现 B RhD 阴性状态与 HBV 感染之间存在关联（OR = 20.174；P > 0.05）。
没有 RhD 抗原的 B 抗原的存在与 HBV 感染的风险增加有关。
