Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Student Researche Committee, Kerman University of Medical Sciences, Kerman, Iran.
Phytother Res. 2022 Aug;36(8):3016-3031. doi: 10.1002/ptr.7496. Epub 2022 Jun 2.
The aim of this systematic review was to identify animal preclinical studies and randomized controlled trials that looked at the effects of R. damascena in any form on different mental diseases. Up to September 2021, the online databases of PubMed, Scopus, Embase, Web of Science, and Cochrane trials, as well as SID and MagIran, were searched. This study included 10 animal studies. Except for one research, the rest of the studies confirmed the positive effects of the plant in treatment of mental disorders. A total of 38 studies met the criteria for inclusion. Individuals who have encountered various sorts of mental problems, such as anxiety, sleep disturbance, and depressive disorder, were studied. R. damascena essential oil (EO), essence, extract, and dried plant were used in aromatherapy and oral administration. A decrease in sympathetic nervous system activity, induction of neurotransmitters, induction of nerve growth factors by neurogenesis and synaptogenesis mechanisms, a decrease in prolactin and an increase in noradrenaline, estradiol, and progesterone secretion are some of the mechanisms of action. In general, R. damascena is an effective herb for the treatment of mental disorders. However, further research timing and duration of intervention are needed to extrapolate the findings.
本系统评价的目的是确定以任何形式研究大马士革玫瑰（R. damascena）对不同精神疾病影响的动物临床前研究和随机对照试验。截至 2021 年 9 月，检索了 PubMed、Scopus、Embase、Web of Science 和 Cochrane 试验以及 SID 和 MagIran 的在线数据库。本研究纳入了 10 项动物研究。除了一项研究外，其余研究均证实了该植物在治疗精神障碍方面的积极作用。共有 38 项研究符合纳入标准。研究对象为患有各种精神问题的个体，如焦虑、睡眠障碍和抑郁障碍。大马士革玫瑰精油（EO）、精华、提取物和干植物被用于芳香疗法和口服。通过神经发生和突触发生机制，降低交感神经系统活动、诱导神经递质、诱导神经生长因子、降低催乳素和增加去甲肾上腺素、雌二醇和孕酮分泌是其作用机制之一。总的来说，大马士革玫瑰是一种治疗精神障碍的有效草药。但是，需要进一步研究干预的时间和持续时间，以推断研究结果。
