Gavra Diana Ioana, Kósa Dóra, Pető Ágota, Józsa Liza, Ujhelyi Zoltán, Fehér Pálma, Pallag Annamária, Ghitea Timea Claudia, Frățilă Simona, Jurca Tünde, Bácskay Ildikó
Department of Preclinical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square 10, H-410068 Oradea, Romania.
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, H-4032 Debrecen, Hungary.
Pharmaceuticals (Basel). 2024 Aug 20;17(8):1092. doi: 10.3390/ph17081092.
Psoriasis is a chronic autoimmune skin condition characterized by red, circumscribed, scaly, and erythematous plaques that can cover large skin areas. While conventional treatments such as topical corticosteroids and systemic medications are commonly prescribed, the interest in natural remedies for psoriasis has grown due to concerns about potential side effects and the desire for alternative treatment options. Mill. is rich in bioactive compounds that possess anti-inflammatory, antioxidant, and antimicrobial properties; these properties make Mill. a promising candidate for the management of skin disorders such as psoriasis. In our previous studies, we successfully formulated and tested different topical preparations containing Mill. In this study, we investigated the correlation between the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores in psoriasis treatment using the abovementioned creams containing Mill. extract. Several tests were performed to study the correlation between the PASI and DLQI scores in psoriasis patients. Consequently, we were able to observe an improvement in terms of the area, induration, desquamation, and erythema; such an improvement implicitly produces an improvement in patients' quality of life. The PASI and DLQI scores showed significant progress between visits. These results confirm Mill. to be a promising candidate for the topical treatment of psoriatic lesions.
银屑病是一种慢性自身免疫性皮肤病,其特征为红色、边界清晰、有鳞屑且呈红斑状的斑块,可覆盖大片皮肤区域。虽然常用的传统治疗方法如局部用皮质类固醇和全身性药物,但由于对潜在副作用的担忧以及对替代治疗方案的需求,对银屑病天然疗法的兴趣有所增加。[植物名称]富含具有抗炎、抗氧化和抗菌特性的生物活性化合物;这些特性使[植物名称]成为治疗银屑病等皮肤疾病的有希望的候选者。在我们之前的研究中,我们成功配制并测试了含有[植物名称]的不同外用制剂。在本研究中,我们使用上述含有[植物名称]提取物的乳膏,研究了银屑病治疗中银屑病面积和严重程度指数(PASI)与皮肤病生活质量指数(DLQI)评分之间的相关性。进行了多项测试以研究银屑病患者PASI和DLQI评分之间的相关性。因此,我们能够观察到在面积、硬结、脱屑和红斑方面有所改善;这种改善必然会使患者的生活质量得到提高。PASI和DLQI评分在各次就诊之间显示出显著进展。这些结果证实[植物名称]是银屑病皮损局部治疗的有希望的候选者。