Department of Plant Pathology, Ohio State University, Columbus, OH 43210, USA; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China; Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
Trends Plant Sci. 2022 Oct;27(10):1063-1076. doi: 10.1016/j.tplants.2022.04.007. Epub 2022 Jun 2.
Mitochondria are energy factories of cells and are important for intracellular interactions with other organelles. Emerging evidence indicates that mitochondria play essential roles in the response to pathogen infection. During infection, pathogens deliver numerous enzymes and effectors into host cells, and some of these effectors target mitochondria, altering mitochondrial morphology, metabolism, and functions. To defend against pathogen attack, mitochondria are actively involved in changing intracellular metabolism, hormone-mediated signaling, and signal transduction, producing reactive oxygen species and reactive nitrogen species and triggering programmed cell death. Additionally, mitochondria coordinate with other organelles to integrate and amplify diverse immune signals. In this review, we summarize recent advances in understanding how mitochondria function in plant immunity and how pathogens target mitochondria for host defense suppression.
线粒体是细胞的能量工厂，对于细胞内与其他细胞器的相互作用非常重要。新出现的证据表明，线粒体在病原体感染的反应中起着至关重要的作用。在感染过程中，病原体将许多酶和效应蛋白输送到宿主细胞中，其中一些效应蛋白靶向线粒体，改变线粒体的形态、代谢和功能。为了抵御病原体的攻击，线粒体积极参与改变细胞内代谢、激素介导的信号转导和信号转导，产生活性氧和活性氮物种，并触发程序性细胞死亡。此外，线粒体与其他细胞器协调，整合和放大各种免疫信号。在这篇综述中，我们总结了近年来在理解线粒体在植物免疫中的功能以及病原体如何针对线粒体来抑制宿主防御方面的最新进展。
