Graduate Program in Department of Exercise Health Science, National Taiwan University of Sport, No. 16, Sec. 1, Shuang-Shih Rd., Taichung, 404, Taiwan.
Department of Sport Performance, National Taiwan University of Sport, Taichung, 404, Taiwan.
Sci Rep. 2022 Jun 3;12(1):9295. doi: 10.1038/s41598-022-13387-8.
Studies have revealed that time-restricted feeding affects the fat oxidation rate; however, its effects on the fat oxidation rate and hyperlipidemia following high-fat meals are unclear. This study investigated the effects of 5-day time-restricted feeding on the fat oxidation rate and postprandial lipemia following high fat meals. In this random crossover experimental study, eight healthy male adults were included each in the 5-day time-restricted feeding trial and the control trial. The meals of the time-restricted feeding trial were provided at 12:00, 16:00, and 20:00. The meals of the control trial were provided at 08:00, 14:00, and 20:00. The contents of the meals of both trials were the same, and the calories of the meals met the 24-h energy requirement of the participants. After 5 days of the intervention, the participants consumed high-fat meals on the sixth day, and their physiological changes were determined. The fasting fat oxidation rate (p < 0.001) and postprandial fat oxidation rate (p = 0.019) of the time-restricted feeding trial were significantly higher than those of the control trial. The 24-h energy consumption and postprandial triglyceride, blood glucose, insulin, glycerol, and free fatty acid concentrations of the two trials showed no significant differences (p > 0.05). The results revealed that 5 days of time-restricted feeding effectively increased the fasting and postprandial fat oxidation rate, but it did not affect postprandial lipemia.
研究表明限时进食会影响脂肪氧化率，但它对高脂肪餐后的脂肪氧化率和高脂血症的影响尚不清楚。本研究旨在探讨 5 天限时进食对高脂肪餐后脂肪氧化率和餐后血脂的影响。在这项随机交叉实验研究中，纳入了 8 名健康男性成年人，分别进行了 5 天的限时进食试验和对照试验。限时进食试验的餐点分别在 12:00、16:00 和 20:00 提供。对照试验的餐点分别在 08:00、14:00 和 20:00 提供。两试验的餐点内容相同，餐点的热量满足参与者 24 小时的能量需求。干预 5 天后，第六天参与者食用高脂肪餐，并测定其生理变化。限时进食试验的空腹脂肪氧化率（p<0.001）和餐后脂肪氧化率（p=0.019）明显高于对照试验。两试验的 24 小时能量消耗和餐后甘油三酯、血糖、胰岛素、甘油和游离脂肪酸浓度无显著差异（p>0.05）。结果表明，5 天限时进食可有效提高空腹和餐后脂肪氧化率，但对餐后血脂无影响。
