Baer P A, Shore A, Ikeman R L
Arthritis Rheum. 1987 Mar;30(3):345-7. doi: 10.1002/art.1780300315.
Our study of 13 hospitalized patients with rheumatoid arthritis examined the effect of intraarticular injection of steroid on serum salicylate levels. A mean decrease in serum salicylate levels of 42 +/- 14.5% was observed in 12 patients within 12-36 hours post-injection (P less than 0.005). This interaction, though transient, may be very significant clinically. It may lead to erroneous conclusions concerning patient compliance, unwarranted increases in salicylate dosage and resultant toxicity, and delay of appropriate therapeutic maneuvers.
我们对13例住院类风湿关节炎患者进行了研究，以考察关节内注射类固醇对血清水杨酸盐水平的影响。12例患者在注射后12 - 36小时内血清水杨酸盐水平平均下降了42±14.5%（P<0.005）。这种相互作用虽然是短暂的，但在临床上可能非常显著。它可能导致关于患者依从性的错误结论、水杨酸盐剂量不必要的增加及其毒性反应，以及延误适当的治疗措施。
