COVID-19 与唐氏综合征：火上浇油。
COVID-19 and Down syndrome: the spark in the fuel.
机构信息
Pathology Advanced Translational Research Unit (PATRU), Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, US.
出版信息
Nat Rev Immunol. 2022 Jul;22(7):404-405. doi: 10.1038/s41577-022-00745-w.
Abstract
In individuals with Down syndrome, immune dysregulation is partially caused by chromosome 21 trisomy. Here, we discuss how these immune differences may result in poorer COVID-19 outcomes, including diminished responses to vaccination and possibly elevated risk for long COVID.
摘要
在唐氏综合征患者中，免疫失调部分是由 21 号染色体三体引起的。在这里，我们讨论这些免疫差异如何导致更差的 COVID-19 结局，包括疫苗接种反应减弱，以及长新冠风险可能增加。
相似文献
1
COVID-19 and Down syndrome: the spark in the fuel.COVID-19 与唐氏综合征：火上浇油。
Nat Rev Immunol. 2022 Jul;22(7):404-405. doi: 10.1038/s41577-022-00745-w.
2
Down syndrome: the aggravation of COVID-19 may be partially justified by the expression of TMPRSS2.唐氏综合征：新冠病毒疾病（COVID-19）的病情加重可能部分归因于跨膜丝氨酸蛋白酶2（TMPRSS2）的表达。
Neurol Sci. 2022 Feb;43(2):789-790. doi: 10.1007/s10072-021-05715-z. Epub 2021 Nov 10.
3
People with Down syndrome face high risk from coronavirus.唐氏综合征患者面临感染新冠病毒的高风险。
Science. 2020 Dec 18;370(6523):1384-1385. doi: 10.1126/science.370.6523.1384.
4
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19.唐氏综合征与严重急性呼吸综合征冠状病毒2的网络分析确定了2019冠状病毒病的风险和保护因素。
Sci Rep. 2021 Jan 21;11(1):1930. doi: 10.1038/s41598-021-81451-w.
5
Are patients with Down syndrome vulnerable to life-threatening COVID-19?唐氏综合征患者是否易感染危及生命的 COVID-19？
Acta Neurol Belg. 2021 Jun;121(3):685-687. doi: 10.1007/s13760-020-01373-8. Epub 2020 May 22.
6
Actions Against Covid-19 in the Down Syndrome Population.针对唐氏综合征人群的新冠疫情应对措施。
Arq Bras Cardiol. 2020 Nov;115(5):939-941. doi: 10.36660/abc.20200685.
7
High case fatality rate in individuals with Down syndrome and COVID-19 in Brazil: a two-year report.巴西唐氏综合征患者与新冠病毒感染的高病死率：一份两年期报告。
J Clin Pathol. 2022 Oct;75(10):717-720. doi: 10.1136/jcp-2021-207802. Epub 2022 Jun 28.
8
Risk of Down syndrome among relatives of Down syndrome individuals.唐氏综合征患者亲属患唐氏综合征的风险。
Am J Med Genet. 1985 Sep;22(1):213-6. doi: 10.1002/ajmg.1320220120.
9
Sound prescriptions to mitigate the effects of COVID-19 in the population with Down syndrome.减轻新冠病毒病对唐氏综合征人群影响的合理处方。
Neurol Sci. 2021 Aug;42(8):3087-3088. doi: 10.1007/s10072-021-05315-x. Epub 2021 May 26.
10
Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome.唐氏综合征合并 COVID-19 肺炎患者：预后不良的高危人群。
Int J Infect Dis. 2021 Feb;103:607-610. doi: 10.1016/j.ijid.2020.11.188. Epub 2020 Nov 30.
引用本文的文献
1
Respiratory support in patients with Down syndrome: a systematic review.唐氏综合征患者的呼吸支持：一项系统评价
Eur Respir Rev. 2025 Feb 5;34(175). doi: 10.1183/16000617.0070-2024. Print 2025 Jan.
2
The dichotomic role of cytokines in aging.细胞因子在衰老过程中的双重作用。
Biogerontology. 2024 Dec 2;26(1):17. doi: 10.1007/s10522-024-10152-4.
3
The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome.唐氏综合征患者来源的单核细胞衍生树突状细胞的免疫反应特征。
Clin Exp Immunol. 2024 Aug 9;217(3):291-299. doi: 10.1093/cei/uxae048.
4
Neuropathological findings in Down syndrome, Alzheimer's disease and control patients with and without SARS-COV-2: preliminary findings.唐氏综合征、阿尔茨海默病患者以及伴有和不伴有 SARS-COV-2 的对照患者的神经病理学发现：初步研究结果。
Acta Neuropathol. 2024 May 27;147(1):92. doi: 10.1007/s00401-024-02743-9.
5
Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21.21三体综合征中对白细胞介素-1抑制有反应的细胞因子风暴综合征
Case Rep Pediatr. 2024 Mar 28;2024:9946401. doi: 10.1155/2024/9946401. eCollection 2024.
6
Cytomegalovirus Pneumonia in a Patient with Down Syndrome.唐氏综合征患者的巨细胞病毒肺炎。
Medicina (Kaunas). 2024 Jan 30;60(2):242. doi: 10.3390/medicina60020242.
7
Mitochondria, Autophagy and Inflammation: Interconnected in Aging.线粒体、自噬和炎症：衰老中的相互关联。
Cell Biochem Biophys. 2024 Jun;82(2):411-426. doi: 10.1007/s12013-024-01231-x. Epub 2024 Feb 21.
8
Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review.增强唐氏综合征个体对 SARS-CoV-2 感染的认识：综合述评。
Sao Paulo Med J. 2023 Aug 21;142(2):e2023015. doi: 10.1590/1516-3180.2023.0015.R1.230523. eCollection 2023.
9
Risk for Severe COVID-19 Outcomes among Persons with Intellectual Disabilities, the Netherlands.具有智力障碍人群感染 COVID-19 后出现重症的风险，荷兰。
Emerg Infect Dis. 2023 Jan;29(1):118-126. doi: 10.3201/eid2901.221346.
10
COVID-19 diverse outcomes: Aggravated reinfection, type I interferons and antibodies.新冠病毒病的多样结局：严重再感染、I型干扰素与抗体。
Med Hypotheses. 2022 Oct;167:110943. doi: 10.1016/j.mehy.2022.110943. Epub 2022 Sep 9.
本文引用的文献
1
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.巴瑞替尼治疗 COVID-19 住院患者的疗效（RECOVERY 研究）：一项随机、对照、开放标签、平台试验及更新的荟萃分析。
Lancet. 2022 Jul 30;400(10349):359-368. doi: 10.1016/S0140-6736(22)01109-6.
2
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells.I 型干扰素转录调控网络调节人 T 细胞共抑制受体的表达。
Nat Immunol. 2022 Apr;23(4):632-642. doi: 10.1038/s41590-022-01152-y. Epub 2022 Mar 17.
3
Safety and Long-Term Immunogenicity of BNT162b2 Vaccine in Individuals with Down Syndrome.BNT162b2疫苗在唐氏综合征患者中的安全性和长期免疫原性。
J Clin Med. 2022 Jan 28;11(3):694. doi: 10.3390/jcm11030694.
4
Autoimmunity and Genetic Syndromes: A Focus on Down Syndrome.自身免疫与遗传综合征：以唐氏综合征为例。
Genes (Basel). 2021 Feb 13;12(2):268. doi: 10.3390/genes12020268.
5
Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19.唐氏综合征与严重急性呼吸综合征冠状病毒2的网络分析确定了2019冠状病毒病的风险和保护因素。
Sci Rep. 2021 Jan 21;11(1):1930. doi: 10.1038/s41598-021-81451-w.
6
Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.唐氏综合征患者感染 COVID-19 后病情更严重。
Genet Med. 2021 Mar;23(3):576-580. doi: 10.1038/s41436-020-01004-w. Epub 2020 Oct 16.
7
Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.唐氏综合征中存在三种四份干扰素受体基因，导致轻度 I 型干扰素病。
J Clin Immunol. 2020 Aug;40(6):807-819. doi: 10.1007/s10875-020-00803-9. Epub 2020 Jun 22.
8
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.SARS-CoV-2 受体 ACE2 是人类气道上皮细胞中的一种干扰素刺激基因，可在组织中的特定细胞亚群中检测到。
Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27.
9
Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination.接种疫苗前的炎症和B细胞信号传导可预测与年龄相关的乙肝疫苗低反应性。
Nat Commun. 2016 Jan 8;7:10369. doi: 10.1038/ncomms10369.
10
Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency?唐氏综合征的免疫评估和疫苗反应：免疫缺陷的证据？
Vaccine. 2011 Jul 12;29(31):5040-6. doi: 10.1016/j.vaccine.2011.04.060. Epub 2011 May 17.
Zotero 插件