Dowle C S, Mitchell A, Elston C W, Roebuck E J, Hinton C P, Holliday H, Blamey R W
Br J Surg. 1987 Mar;74(3):217-9. doi: 10.1002/bjs.1800740323.
Between June 1979 and December 1984, 49,573 women (study population) between the ages of 45 and 64 years and living in one health district were invited to attend breast self-examination sessions as part of the DHSS 'UK Trial of Early Detection of Breast Cancer'. Of the women invited 50.2 per cent attended for education. A total of 319 breast cancers were diagnosed in the study population during this period. The tumour characteristics, patient prognostic groups and survival have been compared with a control population consisting of the 319 consecutive breast cancers diagnosed immediately before the start of the DHSS trial, in women of the same age group and living in the same health district. There has been a significant reduction in the size at presentation of operable tumours (P less than 0.01) and there has been a small (3.4 per cent) reduction in lymph node involvement, but this is not significant. The rates of presentation of both in situ and advanced carcinoma have not significantly changed following the introduction of a breast self-examination education programme. At this stage no overall survival difference has been identified between the two groups but the median follow up of the study population is limited (25 months).
1979年6月至1984年12月期间，居住在某一健康区的49,573名年龄在45至64岁之间的女性（研究人群）被邀请参加乳房自我检查课程，这是英国卫生与社会保障部“乳腺癌早期检测英国试验”的一部分。在被邀请的女性中，50.2%参加了相关教育课程。在此期间，研究人群中总共诊断出319例乳腺癌。已将这些肿瘤特征、患者预后分组及生存率与一个对照人群进行了比较，该对照人群由在英国卫生与社会保障部试验开始前即刻诊断出的319例连续乳腺癌患者组成，这些患者年龄相同且居住在同一健康区。可手术肿瘤的就诊时大小有显著减小（P<0.01），淋巴结受累情况有小幅（3.4%）减少，但不显著。在引入乳房自我检查教育计划后，原位癌和晚期癌的就诊率均未显著改变。现阶段，两组之间未发现总体生存差异，但研究人群的中位随访时间有限（25个月）。
