Locker A P, Caseldine J, Mitchell A K, Blamey R W, Roebuck E J, Elston C W
Nottingham General Hospital, UK.
Br J Cancer. 1989 Sep;60(3):401-5. doi: 10.1038/bjc.1989.294.
This report presents the results of a study into the effect of breast self-examination (BSE) in a large defined population within the City of Nottingham since 1979. We have examined the effect of breast self-examination in a group of patients invited to attend for education in BSE compared with a group of historical controls. No overall survival advantage has been demonstrated for the study group but within the latter group patients who had attended for instruction in BSE had a significantly better actuarial survival at 13 years than those who did not (P less than 0.001). Patients in the study group presented with significantly smaller tumours which were more likely to be of better histological grade and lymph node stage. A case-control study has demonstrated the value of attendance for BSE particularly in post-menopausal women. Although BSE is not as sensitive as mammographic screening, patients who practise it present with more favourable tumour characteristics and its value in post-menopausal women supports its use as an adjunct to mammographic screening.
本报告展示了自1979年以来，对诺丁汉市一大特定人群进行的乳房自我检查（BSE）效果研究的结果。我们对比了一组受邀参加BSE教育的患者与一组历史对照人群，研究了乳房自我检查的效果。研究组未显示出总体生存优势，但在对照组中，参加过BSE指导的患者在13年时的精算生存率显著高于未参加者（P小于0.001）。研究组患者的肿瘤明显更小，更有可能具有更好的组织学分级和淋巴结分期。一项病例对照研究证明了参加BSE的价值，尤其是在绝经后女性中。尽管BSE不如乳腺钼靶筛查敏感，但进行BSE的患者肿瘤特征更有利，其在绝经后女性中的价值支持将其作为乳腺钼靶筛查的辅助手段。
