Department of Surgery, University of California, San Francisco, CA 94143, USA.
Center for Bioengineering and Tissue Regeneration, University of California, San Francisco, San Francisco, CA 94143,USA.
Endocrinology. 2022 Aug 1;163(8). doi: 10.1210/endocr/bqac085.
Mechanical forces collaborate across length scales to coordinate cell fate during development and the dynamic homeostasis of adult tissues. Similarly, steroid hormones interact with their nuclear and nonnuclear receptors to regulate diverse physiological processes necessary for the appropriate development and function of complex multicellular tissues. Aberrant steroid hormone action is associated with tumors originating in hormone-sensitive tissues and its disruption forms the basis of several therapeutic interventions. Prolonged perturbations to mechanical forces may further foster tumor initiation and the evolution of aggressive metastatic disease. Recent evidence suggests that steroid hormone and mechanical signaling intersect to direct cell fate during development and tumor progression. Potential mechanosensitive steroid hormone signaling pathways along with their molecular effectors will be discussed in this context.
机械力在不同尺度上协同作用，以协调发育过程中的细胞命运和成年组织的动态平衡。同样，甾体激素与其核受体和非核受体相互作用，以调节复杂多细胞组织适当发育和功能所必需的多种生理过程。甾体激素作用异常与起源于激素敏感组织的肿瘤有关，其破坏是几种治疗干预的基础。机械力的长期干扰可能进一步促进肿瘤的发生和侵袭性转移疾病的发展。最近的证据表明，甾体激素和机械信号在发育和肿瘤进展过程中相互作用，指导细胞命运。在这方面，将讨论潜在的机械敏感甾体激素信号通路及其分子效应器。
