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鸡体内通过 T1R2 非依赖途径对甜味化合物的行为反应。

Behavioral responses to sweet compounds via T1R2-independent pathways in chickens.

机构信息

Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Laboratory of Functional Anatomy, Faculty of Agriculture, Kyushu University, Fukuoka, Japan; Department of Food and Life Sciences, College of Agriculture, Ibaraki University, Ami, Japan.

出版信息

Poult Sci. 2022 Jul;101(7):101928. doi: 10.1016/j.psj.2022.101928. Epub 2022 Apr 25.

DOI:10.1016/j.psj.2022.101928
PMID:35679679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9189227/
Abstract

Elucidating the taste sensing systems in chickens will enhance our understanding of poultry nutrition and improve the feeding strategies used in poultry farming. It is known that chickens lack the sweet taste receptor subunit, taste receptor type 1 member 2 (T1R2), in their genome. Thus, the present study investigated T1R2-independent sweet-sensing pathways in chickens. RT-PCR analysis revealed that glucose transporters known to play an important role in T1R2-independent sweet sensing in mammals-namely sodium-glucose cotransporter 1 (SGLT1) and ATP-gated K channel subunits-are expressed in the palate, the main taste organ in chickens. In behavioral tests, chickens slightly preferred glucose, galactose, sucrose, maltose, lactose, and stevioside, while high doses of sucrose and fructose were rejected. Chickens did not show any preference for noncaloric sweeteners or sugar alcohol, such as acesulfame K, aspartame, saccharin, sucralose, or sorbitol. The preference for galactose was inhibited by an inhibitor of SGLT1 in a dose-dependent manner. In addition, we found that glucagon-like peptide 1 (GLP-1) and mRNA of the GLP-1 receptor, which are involved specifically in sweet transmission in mice, are also present in the oral tissues of chickens. The present results imply that chickens can sense various sweet compounds via T1R2-independent pathways in oral tissues.

摘要

阐明鸡的味觉感应系统将增进我们对家禽营养的理解，并改善家禽养殖中使用的饲养策略。已知鸡的基因组中缺乏甜味受体亚基 T1R2。因此，本研究调查了鸡中 T1R2 非依赖性的甜味感应途径。RT-PCR 分析显示，在哺乳动物中，已知葡萄糖转运蛋白在 T1R2 非依赖性的甜味感应中发挥重要作用，即钠-葡萄糖协同转运蛋白 1 (SGLT1) 和 ATP 门控 K 通道亚基，在鸡的味觉器官——腭中表达。在行为测试中，鸡对葡萄糖、半乳糖、蔗糖、麦芽糖、乳糖和甜菊糖略有偏好，而高剂量的蔗糖和果糖则被拒绝。鸡对非营养性甜味剂或糖醇，如乙酰磺胺酸钾、阿斯巴甜、糖精、三氯蔗糖或山梨糖醇，没有表现出任何偏好。SGLT1 的抑制剂以剂量依赖性的方式抑制了对半乳糖的偏好。此外，我们发现参与小鼠甜味传递的胰高血糖素样肽 1 (GLP-1) 和 GLP-1 受体的 mRNA 也存在于鸡的口腔组织中。这些结果表明，鸡可以通过口腔组织中的 T1R2 非依赖性途径感知各种甜味化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/b7e57a73aa90/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/b33bdaa3f12c/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/93bbdda5fe14/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/988d5c25b5db/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/7049e512514c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/9783dabcb2c9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/88bd8aee774c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/79637cc5acd8/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/b7e57a73aa90/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/b33bdaa3f12c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/e89708b48e9c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/93bbdda5fe14/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/988d5c25b5db/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/7049e512514c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/9783dabcb2c9/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/88bd8aee774c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/79637cc5acd8/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8746/9189227/b7e57a73aa90/gr9.jpg

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本文引用的文献

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Overlapping distributions of mammalian types I, II, and III taste cell markers in chicken taste buds.哺乳动物 I、II 和 III 型味觉细胞标志物在鸡味蕾中的重叠分布。
Biochem Biophys Res Commun. 2021 Sep 17;570:162-168. doi: 10.1016/j.bbrc.2021.07.025. Epub 2021 Jul 17.
2
The umami receptor T1R1-T1R3 heterodimer is rarely formed in chickens.鲜味受体 T1R1-T1R3 异二聚体在鸡中很少形成。
Sci Rep. 2021 Jun 10;11(1):12318. doi: 10.1038/s41598-021-91728-9.
3
Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue.
Front Physiol. 2023 Sep 8;14:1235377. doi: 10.3389/fphys.2023.1235377. eCollection 2023.
钠-葡萄糖共转运蛋白 1 作为小鼠舌头上的糖味传感器。
Acta Physiol (Oxf). 2020 Dec;230(4):e13529. doi: 10.1111/apha.13529. Epub 2020 Jul 22.
4
Atomistic mechanisms underlying the activation of the G protein-coupled sweet receptor heterodimer by sugar alcohol recognition.糖醇识别激活 G 蛋白偶联甜味受体异源二聚体的原子机制。
Sci Rep. 2019 Jul 15;9(1):10205. doi: 10.1038/s41598-019-46668-w.
5
Short-term perception of and conditioned taste aversion to umami taste, and oral expression patterns of umami taste receptors in chickens.鸡对鲜味的短期感知、条件性味觉厌恶以及鲜味味觉受体的口腔表达模式
Physiol Behav. 2018 Jul 1;191:29-36. doi: 10.1016/j.physbeh.2018.03.020. Epub 2018 Mar 26.
6
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Anim Sci J. 2018 Feb;89(2):441-447. doi: 10.1111/asj.12945. Epub 2017 Nov 27.
7
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