Graur Florin, Puia Aida, Mois Emil Ioan, Moldovan Septimiu, Pusta Alexandra, Cristea Cecilia, Cavalu Simona, Puia Cosmin, Al Hajjar Nadim
Department of Surgery, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
Regional Institute of Gastroenterology and Hepatology "Octavian Fodor", 400394 Cluj-Napoca, Romania.
Materials (Basel). 2022 May 30;15(11):3893. doi: 10.3390/ma15113893.
Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Despite the progress of surgery and chemotherapy, the results are often disappointing, in part due to chemoresistance. This type of tumor has special characteristics that allow the improvement of diagnostic and treatment techniques used in clinical practice, by combining nanotechnology. This article presents a brief review of the literature focused on nano-conditioned diagnostic methods, targeted therapy, and therapeutic implications for the pathology of hepatocellular carcinoma. Within each subdomain, several modern technologies with significant impact were highlighted: serological, imaging, or histopathological diagnosis; intraoperative detection; carrier-type nano-conditioned therapy, thermal ablation, and gene therapy. The prospects offered by nanomedicine will strengthen the hope of more efficient diagnoses and therapies in the future.
肝细胞癌是最常见的肝脏恶性肿瘤，也是最常见的五种癌症之一。尽管手术和化疗取得了进展，但结果往往令人失望，部分原因是化疗耐药性。这种类型的肿瘤具有特殊特征，通过结合纳米技术可改进临床实践中使用的诊断和治疗技术。本文简要回顾了有关纳米条件诊断方法、靶向治疗以及对肝细胞癌病理学的治疗意义的文献。在每个子领域中，都突出了几种具有重大影响的现代技术：血清学、影像学或组织病理学诊断；术中检测；载体型纳米条件治疗、热消融和基因治疗。纳米医学提供的前景将增强未来实现更有效诊断和治疗的希望。
