Department of Cosmetic and Pharmaceutical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
Department of Experimental and Clinical Pharmacology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich Ave. 72, 70-111 Szczecin, Poland.
Molecules. 2022 May 31;27(11):3536. doi: 10.3390/molecules27113536.
L. (EA) has been used as a topical agent since ancient times. There has been an increasing interest in applying EA as a raw material used topically in recent years. However, in the literature, there are not many reports on the comprehensive application of this plant to skin care and treatment. EA contains many valuable secondary metabolites, which determine antioxidant, anti-inflammatory, anti-aging, and antiproliferative activity effects. One of the most important active compounds found in EA is oenothein B (OeB), which increases the level of ROS and protects cells from oxidative damage. OeB also influences wound healing and reduces inflammation by strongly inhibiting hyaluronidase enzymes and inhibiting COX-1 and COX-2 cyclooxygenases. Other compounds that play a key role in the context of application to the skin are flavonoids, which inhibit collagenase and hyaluronidase enzymes, showing anti-aging and anti-inflammatory properties. While terpenes in EA play an important role in fighting bacterial skin infections, causing, among other things cell membrane, permeability increase as well as the modification of the lipid profiles and the alteration of the adhesion of the pathogen to the animal cells. The available scientific information on the biological potential of natural compounds can be the basis for the wider use of EA in skin care and treatment. The aim of the article is to review the existing literature on the dermocosmetic use of .
贯叶连翘（L.）自古以来一直被用作局部药物。近年来，人们对将贯叶连翘作为一种局部使用的原料越来越感兴趣。然而，在文献中，关于这种植物在皮肤护理和治疗方面的综合应用的报道并不多。贯叶连翘含有许多有价值的次生代谢产物，这些物质决定了其抗氧化、抗炎、抗老化和抗增殖的活性作用。在贯叶连翘中发现的最重要的活性化合物之一是奥纳醇 B（OeB），它可以增加 ROS 水平并保护细胞免受氧化损伤。OeB 还通过强烈抑制透明质酸酶和抑制 COX-1 和 COX-2 环氧化酶来影响伤口愈合和减少炎症。在应用于皮肤的情况下发挥关键作用的其他化合物是类黄酮，它可以抑制胶原酶和透明质酸酶，具有抗老化和抗炎作用。虽然贯叶连翘中的萜类化合物在对抗皮肤细菌感染方面发挥着重要作用，除其他外，它会导致细胞膜通透性增加，改变脂质谱，并改变病原体对动物细胞的黏附。关于天然化合物生物潜力的现有科学信息可以为贯叶连翘在皮肤护理和治疗中的更广泛应用提供基础。本文的目的是综述现有的关于贯叶连翘在皮肤护理和治疗中的应用的文献。
