类风湿因子的研究：I. 类风湿因子对小鼠体内预先形成的免疫复合物清除的影响。
Studies on rheumatoid factor: I. The effect of rheumatoid factor on the clearance of preformed immune complexes in mice.
作者信息
Hogben D N, Devey M E
出版信息
Clin Exp Immunol. 1986 Dec;66(3):648-53.
Abstract
The blood clearance of passively transferred immune complexes (IC), preformed at different antigen-antibody ratios, was measured in mice with LPS-induced rheumatoid factor (RF) and in normal controls. RF had a differential effect on IC clearance, significantly enhancing clearance of complexes formed in antibody excess and slight antigen excess but inhibiting the clearance of complexes formed in moderate (x10) antigen excess. The results are discussed with regard to the mechanisms of IC clearance and suggest that RF may play an important role in governing the behaviour of immune complexes in vivo.
摘要
在脂多糖诱导产生类风湿因子（RF）的小鼠和正常对照小鼠中，测定了以不同抗原抗体比例预先形成的被动转移免疫复合物（IC）的血液清除率。RF对IC清除具有不同影响，显著增强了抗体过量和轻微抗原过量时形成的复合物的清除，但抑制了中等程度（x10）抗原过量时形成的复合物的清除。就IC清除机制对结果进行了讨论，结果表明RF可能在体内调控免疫复合物行为方面发挥重要作用。
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