Department of Biomedical EngineeringCase Western Reserve University Cleveland OH 44106 USA.
Advanced Platform Technology CenterLouis Stokes Cleveland Veterans Affairs Medical Center Cleveland OH 44106 USA.
IEEE J Transl Eng Health Med. 2022 May 4;10:4900909. doi: 10.1109/JTEHM.2022.3172847. eCollection 2022.
Wound dressings that create and maintain a moist environment provide the optimal conditions for wound healing by increasing the rate of epithelialization and angiogenesis. However, current wound dressings require periodic removal which exposes the wound to the surrounding environment, thereby increasing the likelihood for infection and drying out the wound itself. There remains an unmet medical need for the development of an absorbent, flexible, and transparent wound dressing that can conform to the irregular geometry of the wound for a long-term duration. Herein, we report the development of Derm, an Absorbent, Flexible, Transparent, and Inexpensive moisture-management wound dressing using Polyvinyl alcohol (PVA) as the host material. Derm substrates of varying glycerol concentrations (1 wt%, 3 wt%, 5 wt%, 7 wt%, and 10 wt%) were fabricated and tested. The mechanical, absorption, and biological properties of Derm were evaluated. We found that 5% glycerol served as the optimal concentration for Derm. The biocompatibility, absorptive capabilities, and scalability render PVA/glycerol an ideal material composition for wound dressings. Benchtop experimentation and pre-clinical testing demonstrate Derm as a platform for use in wound dressings. The development of Derm broadens the translational utility of this materials platform not only as a material for wound dressings to minimize dressing changes in low to moderate exudate environments, but also as a potential substrate material for smart bandages. Derm, an absorbent, flexible, and transparent wound dressing, maintains the moist environment required for healing while enabling monitoring of healing without removal and disruption to the wound bed.
伤口敷料创造并维持湿润环境，通过增加上皮化和血管生成的速度，为伤口愈合提供最佳条件。然而，目前的伤口敷料需要定期更换，这会使伤口暴露在周围环境中，从而增加感染和伤口干燥的可能性。因此，人们仍然需要开发一种具有吸水性、柔韧性和透明性的伤口敷料，可以长期适应伤口的不规则几何形状。在这里，我们报告了 Derm 的开发，这是一种使用聚乙烯醇 (PVA) 作为宿主材料的吸水性、柔韧性、透明性和廉价的水分管理伤口敷料。制备并测试了不同甘油浓度（1wt%、3wt%、5wt%、7wt%和 10wt%）的 Derm 基底。评估了 Derm 的机械、吸收和生物性能。我们发现 5%的甘油是 Derm 的最佳浓度。PVA/甘油的生物相容性、吸收能力和可扩展性使其成为伤口敷料的理想材料组成。台式实验和临床前测试表明，Derm 是伤口敷料的一个平台。Derm 的开发不仅拓宽了这种材料平台作为伤口敷料的转化用途，可以减少低到中度渗出环境下的敷料更换，而且还可以作为智能绷带的潜在基板材料。吸水性、柔韧性和透明的 Derm 伤口敷料在保持愈合所需的湿润环境的同时，能够在不更换和破坏伤口床的情况下监测愈合情况。
