Yu Flora, Lau Lok-Ting, Fok Manson, Lau Johnson Yiu-Nam, Zhang Kang
Department of Natural Sciences and Mathematics, University of Texas at Dallas, Richardson, Texas 75080-3021, USA.
Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR 999077, China.
Precis Clin Med. 2021 Sep 20;4(4):287-292. doi: 10.1093/pcmedi/pbab024. eCollection 2021 Dec.
The SARS-CoV-2 Delta variant has evolved as the dominant strain of the current pandemic. Studies have shown that this variant has increased infectivity/viral load, and reduced neutralization by the host antibodies from convalescent patients/vaccinees. Clinically, Delta variant infection has been observed/documented in convalescent patients/vaccinees, although with less incidence of severe diseases, but can serve as reservoir to spread the infection to the unvaccinated. The current understanding (as of 18 August 2021) on the virologic aspect (including the amino acid substitutions), clinical implications, and public health implications will be discussed in this mini review, and recommendations to health authorities will be provided.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的德尔塔变异株已演变为当前大流行的主要毒株。研究表明，该变异株的传染性/病毒载量增加，康复患者/疫苗接种者体内的宿主抗体对其的中和作用减弱。临床上，在康复患者/疫苗接种者中已观察到/记录到德尔塔变异株感染，尽管重症疾病的发生率较低，但它可作为传染源将感染传播给未接种疫苗的人群。本综述将讨论目前（截至2021年8月18日）对该变异株病毒学方面（包括氨基酸替换）、临床意义和公共卫生意义的认识，并向卫生当局提供相关建议。
