Wumba R, Mandina M, Nlandu Y, Makulo J R, Tshimpi A, Mbala P, Mbangama A, Kabututu P, Kayembe J M
Service of Parasitology, Department of Tropical Medicine, Infectious and Parasitic Diseases, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Service of Infectious and Parasitic Diseases, Department of Internal Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo.
Interdiscip Perspect Infect Dis. 2022 Jun 2;2022:7856659. doi: 10.1155/2022/7856659. eCollection 2022.
The pathogenic mechanisms and immune response of COVID-19 are far from clear. Through a documentary review of literature, the authors describe virological and molecular aspects of SARS-CoV-2, the intimate mechanisms of cell infection, and potential therapeutic targets. They also analyze the characteristics of immune response of the infected subject.
Objectives of this study are to describe the state of knowledge on virological data, molecular and physiopathogenic mechanisms of SARS-CoV-2, with a view to a better understanding of the therapeutic targets, as well as the immune response of the infected subject. . This documentary review is a compilation of several meta-analyses, consistent with the methodology described in the PRISMA statement on literature data on SARS-CoV-2, published between March 22 and August 14, 2020 (Moher et al.). The search engines used for the selection of articles were as follows: PubMed, Google Scholar, Global Health, and WHO reports. Papers of interest were those addressing virological and molecular data on SARS-CoV-2, therapeutic aspects of COVID-19, and immunity of the infected subject. Of the 617 eligible papers, 417 could be retained after removing the duplicates. Ultimately, only 50 articles were retained for final evaluation. The data collected allowed the development of a two-armed model around the physiopathological aspects and potential therapeutic targets, as well as aspects of host immunity, respectively. The model was then compared to data from the HIV literature.
Reported data could contribute to a better understanding of molecular mechanisms of cellular infection by SARS-CoV-2 as well as to a more easy explanation of the action of pharmacological agents used for the treatment, while elucidating intimate mechanisms of the immunity of infected subject.
新型冠状病毒肺炎（COVID-19）的致病机制和免疫反应尚不清楚。通过文献综述，作者描述了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的病毒学和分子学方面、细胞感染的内在机制以及潜在的治疗靶点。他们还分析了感染患者的免疫反应特征。
本研究的目的是描述SARS-CoV-2的病毒学数据、分子和生理致病机制的知识状态，以便更好地理解治疗靶点以及感染患者的免疫反应。 本综述是多项荟萃分析的汇编，符合2020年3月22日至8月14日发表的关于SARS-CoV-2文献数据的PRISMA声明中描述的方法（Moher等人）。用于筛选文章的搜索引擎如下：PubMed、谷歌学术、全球卫生和世界卫生组织报告。感兴趣的论文是那些涉及SARS-CoV-2的病毒学和分子数据、COVID-19的治疗方面以及感染患者的免疫的论文。在617篇符合条件的论文中，去除重复项后保留了417篇。最终，仅保留50篇文章进行最终评估。收集的数据分别围绕生理病理方面、潜在治疗靶点以及宿主免疫方面建立了一个双臂模型。然后将该模型与来自艾滋病文献的数据进行比较。
报告的数据有助于更好地理解SARS-CoV-2细胞感染的分子机制，也有助于更轻松地解释用于治疗的药物的作用，同时阐明感染患者免疫的内在机制。
