Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Future Oncol. 2022 Jul;18(22):2483-2494. doi: 10.2217/fon-2021-1158. Epub 2022 Jun 13.
Breast cancer is a common cancer in the female population. Despite remarkable progress in the treatment of this cancer, its exact etiology is still unknown. Since the first evidence of an association between breast cancer and human papillomavirus (HPV) was provided in 1992, numerous studies have explored this subject but have reached contradictory results. In this review, the authors examine the existing evidence and hypotheses regarding the pathways whereby HPV infection can reach breast cells and the mediators linking HPV oncoproteins to breast cancer pathogenesis. Furthermore, the authors discuss contradictory findings regarding the association of HPV with breast cancer. Showing the link between HPV infection and increased genomic instability, reduced apoptosis, immune system dysfunction and progression of metastasis, the reviewed findings highlight the importance of active presence or history of HPV infection as a prognostic factor for breast tumor development.
乳腺癌是女性人群中常见的癌症。尽管在这种癌症的治疗方面取得了显著进展，但它的确切病因仍不清楚。自 1992 年首次提供乳腺癌与人类乳头瘤病毒（HPV）之间存在关联的证据以来，许多研究都探讨了这一主题，但得出了相互矛盾的结果。在这篇综述中，作者检查了关于 HPV 感染如何到达乳腺细胞的途径以及将 HPV 致癌蛋白与乳腺癌发病机制联系起来的介质的现有证据和假设。此外，作者还讨论了 HPV 与乳腺癌之间关联的矛盾发现。综述结果表明 HPV 感染与基因组不稳定性增加、细胞凋亡减少、免疫系统功能障碍和转移进展之间存在联系，强调了 HPV 感染的活跃存在或既往感染作为乳腺肿瘤发展的预后因素的重要性。
