Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, 323 National Road, Ganzhou, 341000, Jiangxi, China.
The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Rev Endocr Metab Disord. 2022 Oct;23(5):1011-1033. doi: 10.1007/s11154-022-09740-x. Epub 2022 Jun 13.
As one of the most widespread chronic diseases, diabetes and its accompanying complications affect approximately one tenth of individuals worldwide and represent a growing cause of morbidity and mortality. Accumulating evidence has proven that the process of diabetes is complex and interactive, involving various cellular responses and signaling cascades by posttranslational modifications (PTMs). Therefore, understanding the mechanisms and functions of PTMs in regulatory networks has fundamental importance for understanding the prediction, onset, diagnosis, progression, and treatment of diabetes. In this review, we offer a holistic summary and illustration of the crosstalk between PTMs and diabetes, including both types 1 and 2. Meanwhile, we discuss the potential use of PTMs in diabetes treatment and provide a prospective direction for deeply understanding the metabolic diseases.
作为最广泛的慢性疾病之一，糖尿病及其伴随的并发症影响了全球约十分之一的人口，是发病率和死亡率不断上升的主要原因。越来越多的证据表明，糖尿病的发生是一个复杂的、相互作用的过程，涉及多种细胞反应和信号级联反应，通过翻译后修饰（PTM）来实现。因此，了解调控网络中 PTM 的机制和功能对于理解糖尿病的预测、发病、诊断、进展和治疗具有重要意义。在这篇综述中，我们全面总结和说明了 PTM 与 1 型和 2 型糖尿病之间的相互作用，并讨论了 PTM 在糖尿病治疗中的潜在应用，为深入了解代谢性疾病提供了前瞻性方向。
