Bostancı Nazlı Seray, Büyüksungur Senem, Hasirci Nesrin, Tezcaner Ayşen
Department of Biotechnology, Middle East Technical University (METU), Ankara, Turkey.
Center of Excellence in Biomaterials and Tissue Engineering, METU BIOMATEN, Ankara, Turkey.
J Biomater Sci Polym Ed. 2022 Oct;33(14):1866-1900. doi: 10.1080/09205063.2022.2088525. Epub 2022 Jun 24.
Pectin is a polysaccharide extracted from various plants, such as apples, oranges, lemons, and it possesses some beneficial effects on human health, including being hypoglycemic and hypocholesterolemic. Therefore, pectin is used in various pharmaceutical and biomedical applications. Meanwhile, its low mechanical strength and fast degradation rate limit its usage as drug delivery devices and tissue engineering scaffolds. To enhance these properties, it can be modified or combined with other organic molecules or polymers and/or inorganic compounds. These materials can be prepared as nano sized drug carriers in the form of spheres, capsules, hydrogels, self assamled micelles, etc., for treatment purposes (mostly cancer). Different composites or blends of pectin can also be produced as membranes, sponges, hydrogels, or 3D printed matrices for tissue regeneration applications. This review is concentrated on the properties of pectin based materials and focus especially on the utilization of these materials as drug carriers and tissue engineering scaffolds, including 3D printed and 3D bioprinted systems covering the studies in the last decade and especially in the last 5 years.
果胶是一种从苹果、橙子、柠檬等多种植物中提取的多糖，它对人体健康具有一些有益作用，包括降血糖和降胆固醇。因此，果胶被用于各种制药和生物医学应用中。同时，其较低的机械强度和较快的降解速率限制了它作为药物递送装置和组织工程支架的应用。为了增强这些性能，可以对其进行改性，或将其与其他有机分子、聚合物和/或无机化合物结合。这些材料可以制备成纳米级药物载体，呈球形、胶囊、水凝胶、自组装胶束等形式，用于治疗目的（主要是癌症）。果胶的不同复合材料或共混物也可以制成膜、海绵、水凝胶或3D打印基质，用于组织再生应用。本综述集中于基于果胶的材料的性能，尤其关注这些材料作为药物载体和组织工程支架的应用，包括3D打印和3D生物打印系统，涵盖过去十年尤其是过去五年的研究。
