Latella Raffaella, Calzoni Eleonora, Urbanelli Lorena, Cerrotti Giada, Porcellati Serena, Emiliani Carla, Buratta Sandra, Tancini Brunella
Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy.
Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, Via del Giochetto, 06123 Perugia, Italy.
Foods. 2024 May 11;13(10):1492. doi: 10.3390/foods13101492.
Agri-food wastes generated by industrial food processing are valorized through the extraction of biomolecules to obtain value-added products useful for various industrial applications. In the present review, we describe the valuable by-products and bioactive molecules that can be obtained from agricultural wastes and propose extracellular vesicles (EVs) as innovative nutraceutical and therapeutic compounds that could be derived from agriculture residues. To support this idea, we described the general features and roles of EVs and focused on plant-derived extracellular vesicles (PDEVs) that are considered natural carriers of bioactive molecules and are involved in intercellular communication between diverse kingdoms of life. Consistently, PDEVs exert beneficial effects (anti-inflammatory, anti-tumor, and immune-modulatory) on mammalian cells. Although this research field is currently in its infancy, in the near future, the isolation of EVs and their use as nutraceutical tools could represent a new and innovative way to valorize waste from the agri-food industry in an ecofriendly way.
工业食品加工产生的农业食品废弃物通过提取生物分子进行增值利用，以获得可用于各种工业应用的增值产品。在本综述中，我们描述了可从农业废弃物中获得的有价值的副产品和生物活性分子，并提出细胞外囊泡（EVs）作为可从农业残留物中衍生的创新营养和治疗化合物。为支持这一观点，我们描述了EVs的一般特征和作用，并重点关注植物来源的细胞外囊泡（PDEVs），它们被认为是生物活性分子的天然载体，参与不同生命王国之间的细胞间通讯。一致地，PDEVs对哺乳动物细胞发挥有益作用（抗炎、抗肿瘤和免疫调节）。尽管这个研究领域目前尚处于起步阶段，但在不久的将来，EVs的分离及其作为营养工具的使用可能代表一种以生态友好方式使农业食品工业废弃物增值的新的创新方法。
