Veterinary Sciences Graduate Program, Department of Veterinary Medicine, Federal University of Paraná, Juvevê, Curitiba, PR, Brazil; Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Veterinary Sciences Graduate Program, Department of Veterinary Medicine, Federal University of Paraná, Juvevê, Curitiba, PR, Brazil.
Vet Anaesth Analg. 2022 Sep;49(5):468-472. doi: 10.1016/j.vaa.2022.04.006. Epub 2022 Apr 30.
To evaluate the sedative effects of a combination of sufentanil and midazolam administered intramuscularly (IM) or intranasally (IN) prior to induction of anesthesia with propofol in New Zealand White rabbits.
Prospective, randomized, crossover, experimental study.
A total of 11 adult New Zealand White rabbits.
Sufentanil (0.5 μg kg) and midazolam (2 mg kg) were administered to rabbits via IM or IN route. The righting reflex was assessed, and sedation was scored. Heart rate, respiratory rate (f) and temperature were recorded prior to treatment administration and after loss of the righting reflex.
Measured variables remained within normal physiologic ranges for all rabbits. The only statistically significant change was for f, which was significantly lower after sedation for both routes. The time to loss of righting reflex was 14.8 ± 6.5 and 12.5 ± 7.4 minutes and sedation scores were 6 (4-8) and 7 (6-8) for IM and IN routes, respectively, with no difference between treatments. No adverse effects were observed during the experimental period.
Sufentanil combined with midazolam administered either IM or IN resulted in moderate to deep sedation in New Zealand White rabbits at the dose rates studied.
评估在新西兰白兔中，在异丙酚诱导麻醉前肌内（IM）或鼻内（IN）给予舒芬太尼和咪达唑仑联合应用的镇静效果。
前瞻性、随机、交叉、实验研究。
共 11 只成年新西兰白兔。
通过 IM 或 IN 途径给予舒芬太尼（0.5μg/kg）和咪达唑仑（2mg/kg）。评估翻正反射，并进行镇静评分。在治疗前和失去翻正反射后记录心率、呼吸频率（f）和体温。
所有兔子的测量变量均保持在正常生理范围内。唯一具有统计学意义的变化是 f，两种途径的镇静后 f 均显著降低。失去翻正反射的时间分别为 14.8±6.5 和 12.5±7.4 分钟，IM 和 IN 途径的镇静评分分别为 6（4-8）和 7（6-8），两种治疗方法之间无差异。在实验期间未观察到不良反应。
在研究剂量下，舒芬太尼联合咪达唑仑通过 IM 或 IN 给药在新西兰白兔中产生中度至深度镇静。
