含留兰香、香薄荷和牛至精油的固体脂质纳米粒具有良好的杀幼虫效果，可防治主要疟疾传播媒介按蚊属斯蒂芬斯。
Promising Larvicidal Efficacy of Solid Lipid Nanoparticles Containing Mentha longifolia L., Mentha pulegium L., and Zataria multiflora Boiss. Essential Oils Against the Main Malaria Vector, Anopheles stephensi Liston.
机构信息
Department of Medical Entomology and Vector Control, School of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
出版信息
Acta Parasitol. 2022 Sep;67(3):1265-1272. doi: 10.1007/s11686-022-00580-y. Epub 2022 Jun 15.
PURPOSE
An attempt was made in the current study to develop a natural mosquito larvicide using nanotechnology.
METHODS
Solid lipid nanoparticles (SLNs) containing three essential oils were first prepared using the high-pressure homogenizer. Larvicidal effects of essential oils and the SLNs against Anopheles stephensi were then compared.
RESULTS
The size of SLN containing Mentha longifolia, Mentha pulegium, Zataria multiflora essential oil was obtained as 105 ± 7, 210 ± 4, and 137 ± 8 nm. Their zeta potentials were - 7.8, - 4.7, and - 9.7 mV. Besides, their efficacy with LC values of 24.79, 5.11, and 9.19 µg/mL was significantly more potent than that of their un-formulated essential oils with LC values of 36.2, 27.55, and 33.33 µg/mL.
CONCLUSION
SLNs containing M. pulegium with the best efficacy (P < 0.05) could be considered as potent larvicides against other important species of mosquitoes and field trials.
目的
本研究试图利用纳米技术开发一种天然的杀蚊剂。
方法
首先使用高压匀质机制备含有三种精油的固体脂质纳米粒（SLN）。然后比较精油和 SLN 对致倦库蚊的杀蚊效果。
结果
含留兰香、神香草、缬草精油的 SLN 的粒径分别为 105±7、210±4 和 137±8nm。它们的 Zeta 电位分别为-7.8、-4.7 和-9.7mV。此外，它们的功效明显优于未成型的精油，LC 值分别为 24.79、5.11 和 9.19μg/mL，而其 LC 值分别为 36.2、27.55 和 33.33μg/mL。
结论
含神香草精油的 SLN 具有最佳功效（P<0.05），可考虑作为其他重要蚊种的有效杀蚊剂，并进行田间试验。
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