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结节病患者中抑制性单核细胞对多克隆B细胞激活的抑制作用。

Inhibition of polyclonal B-cell activation by suppressor monocytes in patients with sarcoidosis.

作者信息

Katz P, Fauci A S

出版信息

Clin Exp Immunol. 1978 Jun;32(3):554-62.

PMID:357055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541315/
Abstract

The present study employed a direct plaque-forming cell (PGC) assay following pokeweed mitogen (PWM) induced polyclonal activation of B lymphocytes in sarcoidosis to evaluate the in vitro humoral immune response in this disease and to delineate the immunoregulation of this response. Sarcoidosis lymphocytes had a suppressed PFC response to polyclonal activation, but were unable to suppress normal B-cell PFC responses in allogeneic co-cultures. Removal of a cell type, which was corticosteroid-resistant, radio-resistant, adherent and a non-T cell, from sarcoidosis mononuclear cell suspensions reversed the suppressed PFC response, indicating the presence of a suppressor monocyte. Thus in vitro suppressor cell activity has now been demonstrated in this disease, which is characterized by multiple immunological aberrancies.

摘要

本研究采用在结节病中经商陆丝裂原（PWM）诱导B淋巴细胞多克隆激活后的直接空斑形成细胞（PFC）测定法，以评估该疾病的体外体液免疫反应，并阐明这种反应的免疫调节。结节病淋巴细胞对多克隆激活的PFC反应受到抑制，但在同种异体共培养中无法抑制正常B细胞的PFC反应。从结节病单核细胞悬液中去除一种对皮质类固醇耐药、对辐射耐药、贴壁且非T细胞的细胞类型，可逆转受抑制的PFC反应，表明存在抑制性单核细胞。因此，现已在这种以多种免疫异常为特征的疾病中证明了体外抑制细胞活性。

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本文引用的文献

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IN-VITRO STUDIES OF LYMPHOCYTES FROM PATIENTS WITH SARCOIDOSIS AND LYMPHOPROLIFERATIVE DISEASES.结节病和淋巴增殖性疾病患者淋巴细胞的体外研究。
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Changes in rheumatoid factor activity during the course of sarcoidosis.结节病病程中类风湿因子活性的变化。
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Evidence for circulating immune complexes in sarcoidosis.结节病中循环免疫复合物的证据。
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Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes.神经氨酸酶处理的绵羊红细胞与人类T淋巴细胞的结合增强。
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Sarcoidosis, another disease associated with serologic evidence for herpes-like virus infection.结节病，另一种与疱疹样病毒感染的血清学证据相关的疾病。
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Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.抑制性T细胞在常见变异型低丙种球蛋白血症发病机制中的作用。
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