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含氧化铁配方对有色人种皮肤中可见光诱导色素沉着的影响。

Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals.

出版信息

J Drugs Dermatol. 2020 Jul 1;19(7):712-717. doi: 10.36849/JDD.2020.5032.

Abstract

Visible light (400-700nm), which contributes to 45% of solar radiation, contributes to skin darkening and worsening of dyschromias, particularly in individuals with Fitzpatrick skin phototypes III and higher. Currently, sunscreens provide limited protection against that spectrum. Due to their capabilities in absorbing, scattering, and reflecting visible light, topical products containing pigments and/or metal oxides can provide additional photoprotection. In this study, the efficacy of two formulations containing iron oxide was evaluated in preventing visible light-induced pigmentation compared with a non-tinted mineral SPF 50+ sunscreen. Expert grading and colorimetry demonstrated that the iron-oxide containing formulations significantly protected against visible light-induced pigmentation compared to untreated skin or mineral SPF 50+ sunscreen in Fitzpatrick IV individuals. These results highlight that iron-oxide containing formulas in a foundation format have dual functions and can provide additional benefits in patients' daily routine by masking existing pigmentation and preventing the development of pigmentation triggered by sunlight exposure, extending protection beyond UV spectrum. J Drugs Dermatol. 2020;19(7): doi:10.36849/JDD.2020.5032 THIS ARTICLE HAD BEEN MADE AVAILABLE FREE OF CHARGE. PLEASE SCROLL DOWN TO ACCESS THE FULL TEXT OF THIS ARTICLE WITHOUT LOGGING IN. NO PURCHASE NECESSARY. PLEASE CONTACT THE PUBLISHER WITH ANY QUESTIONS.

摘要

可见光(400-700nm)占太阳辐射的 45%,可导致皮肤变黑和色素沉着恶化,尤其在 Fitzpatrick 皮肤光型 III 及更高的人群中。目前,防晒霜对该光谱的防护作用有限。由于含有颜料和/或金属氧化物的局部用产品具有吸收、散射和反射可见光的能力,因此可以提供额外的光保护。在这项研究中,评估了两种含有氧化铁的配方在预防可见光诱导的色素沉着方面的功效,与非有色矿物 SPF50+防晒霜进行了比较。专家评分和比色法表明,与未处理的皮肤或 Fitzpatrick IV 个体中的矿物 SPF50+防晒霜相比,含有氧化铁的配方可显著预防可见光诱导的色素沉着。这些结果表明,粉底形式的含有氧化铁的配方具有双重功能,可以通过掩盖现有色素沉着和预防阳光暴露引发的色素沉着来为患者的日常生活提供额外的益处,将保护作用扩展到 UV 光谱之外。J 皮肤病药物杂志。2020;19(7):doi:10.36849/JDD.2020.5032 本文已免费提供。请向下滚动访问此文章的全文,无需登录。无需购买。如有任何疑问,请与出版商联系。

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