非编码RNA：阿尔茨海默病中一种协同抗凋亡的治疗工具。
NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease.
作者信息
Li Liangxian, Jin Mingyue, Tan Jie, Xiao Bo
机构信息
Laboratory of Respiratory Disease, Affiliated Hospital of Guilin Medical University, Guilin, China.
Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, China.
出版信息
CNS Neurosci Ther. 2024 Apr;30(4):e14476. doi: 10.1111/cns.14476. Epub 2023 Sep 22.
AIMS
The aim of this review is to systematically summarize and analyze the noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the cell apoptosis among Alzheimer's disease (AD) in recent years to demonstrate their value in the diagnosis and treatment of AD.
METHODS
We systematically summarized in vitro and in vivo studies focusing on the ncRNAs in the regulation of cell apoptosis among AD in PubMed, ScienceDirect, and Google Scholar.
RESULTS
We discover three patterns of ncRNAs (including 'miRNA-mRNA', 'lncRNA-miRNA-mRNA', and 'circRNA-miRNA-mRNA') form the ncRNA-based regulatory networks in regulating cell apoptosis in AD.
CONCLUSIONS
This review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.
目的
本综述旨在系统总结和分析近年来阿尔茨海默病（AD）细胞凋亡中的非编码RNA（ncRNA），特别是微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），以阐明它们在AD诊断和治疗中的价值。
方法
我们在PubMed、ScienceDirect和谷歌学术上系统总结了聚焦于ncRNA在AD细胞凋亡调控中的体外和体内研究。
结果
我们发现三种ncRNA模式（包括“miRNA- mRNA”、“lncRNA-miRNA-mRNA”和“circRNA-miRNA-mRNA”）在AD细胞凋亡调控中形成了基于ncRNA的调控网络。
结论
本综述为基于ncRNA的AD患者未来诊断和治疗策略提供了依据。
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