需氧和厌氧条件下多形核中性粒细胞的趋化作用。
Polymorphonuclear neutrophil chemotaxis under aerobic and anaerobic conditions.
作者信息
Casciato D A, Goldberg L S, Bluestone R
出版信息
Infect Immun. 1978 Aug;21(2):381-6. doi: 10.1128/iai.21.2.381-386.1978.
The motility of human polymorphonuclear neutrophils was studied in vitro under aerobic and anaerobic conditions. Chemotactic factors were generated from plasma with immune complexes or with whole bacteria (Staphylococcus aureus, Escherichia coli, and Bacteroides fragilis). Chemotaxis induced by chemotactic factors generated from immune complexes was identical under both conditions. However, chemotaxis utilizing chemotactic factors generated from bacteria was markedly depressed under anaerobic conditions. Mean random tubemoltility was not significantly different under aerobic and anaerobic conditions. These data indicate that different metabolic pathways may be involved in polymorphonuclear neutrophil movement. Some of these pathways require oxygen (chemotaxis in response to factors generated by bacteria in plasma), whereas others do not (random tube migration and chemotaxis in response to factors generated by immune complexes in plasma). These observations may be important in the induction of inflammatory responses within hypoxic tissues.
在需氧和厌氧条件下，对人多形核中性粒细胞的运动性进行了体外研究。趋化因子由血浆与免疫复合物或全菌（金黄色葡萄球菌、大肠杆菌和脆弱拟杆菌）产生。在两种条件下，由免疫复合物产生的趋化因子诱导的趋化作用是相同的。然而，在厌氧条件下，利用细菌产生的趋化因子的趋化作用明显受到抑制。在需氧和厌氧条件下，平均随机管内运动性没有显著差异。这些数据表明，多形核中性粒细胞的运动可能涉及不同的代谢途径。其中一些途径需要氧气（对血浆中细菌产生的因子的趋化作用），而其他途径则不需要（随机管迁移和对血浆中免疫复合物产生的因子的趋化作用）。这些观察结果可能对缺氧组织内炎症反应的诱导很重要。
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