一种葡萄球菌因子对白细胞迁移的抑制作用。
Inhibition of leukocyte migration by a staphylococcal factor.
作者信息
Weksler B B, Hill M J
出版信息
J Bacteriol. 1969 Jun;98(3):1030-5. doi: 10.1128/jb.98.3.1030-1035.1969.
Abstract
Cell wall mucopeptide isolated from virulent strains of Staphylococcus aureus has previously been found to potentiate subcutaneous staphylococcal lesions in mice. This cell wall fraction was found to inhibit the migration of polymorphonuclear leukocytes toward a chemotactic stimulus, as tested by the micropore filter chamber technique. A close correlation was shown to exist between in vivo "mouse virulence" of staphylococcal strains and the in vitro inhibition of leukocyte migration by the cell wall factor.
摘要
先前已发现，从金黄色葡萄球菌的强毒株中分离出的细胞壁粘肽可增强小鼠皮下葡萄球菌感染病灶。通过微孔滤膜小室技术检测发现，这种细胞壁组分可抑制多形核白细胞向趋化刺激物的迁移。结果表明，葡萄球菌菌株的体内“小鼠毒力”与细胞壁因子对白细胞迁移的体外抑制作用之间存在密切相关性。
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