Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Cancer Epidemiol. 2022 Aug;79:102201. doi: 10.1016/j.canep.2022.102201. Epub 2022 Jun 18.
Consumption of sweetened beverages has been linked to several risk factors for liver cancer including diabetes. Studies investigating the role of sweetened beverage consumption and liver cancer, however, are limited. As persons with diabetes are advised against consumption of sugar, the objective of this study was to examine the role of sweetened beverage consumption and liver cancer risk by diabetes status.
Data from two U.S. cohorts: the NIH-AARP Diet and Health Study, and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial were harmonized and pooled. Hazard ratios and 95%CI were estimated using Cox proportional hazard models stratified by median follow-up time.
Among persons without diabetes, there were no statistical evidence of associations between liver cancer and consumption of sweetened beverages overall, sugar sweetened beverages (SSB), or artificially sweetened beverages (ASB). Sugar sweetened (SS) soda consumption, however, was associated with liver cancer in the first follow-up interval (HR:1.18. 95%CI: 1.03, 1.35). In contrast, among persons with diabetes, there were significant associations between liver cancer and consumption of sweetened beverages overall (HR: 1.12, 95%CI 1.01, 1.24), ASBs (HR: 1.13, 95% CI: 1.02, 1.25), soda overall (HR: 1.13, 95% CI: 1.00, 1.26) and artificially sweetened (AS) soda (HR: 1.13, 95% CI: 1.01, 1.27) in the first follow-up interval.
Increased soda consumption may be associated with risk of liver cancer. The results suggest that decreasing consumption of SS soda by persons without diabetes, and AS soda by persons with diabetes, could be associated with reduced liver cancer risk.
摄入含糖饮料与多种肝癌风险因素有关，包括糖尿病。然而，研究含糖饮料摄入与肝癌的关系的研究有限。由于糖尿病患者被建议避免摄入糖，因此本研究旨在根据糖尿病状况研究含糖饮料摄入与肝癌风险的关系。
数据来自两个美国队列：美国国立卫生研究院-美国退休人员协会饮食与健康研究和前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验，进行了协调和汇总。使用按中位随访时间分层的 Cox 比例风险模型估计风险比和 95%置信区间。
在没有糖尿病的人群中，总体上没有证据表明肝癌与含糖饮料、含糖饮料（SSB）或人工甜味饮料（ASB）的摄入有关。然而，在第一个随访间隔中，糖精（SS）苏打水的消费与肝癌有关（HR：1.18. 95%CI：1.03，1.35）。相比之下，在患有糖尿病的人群中，总体上与肝癌的发生存在显著关联，包括含糖饮料（HR：1.12，95%CI 1.01，1.24）、ASBs（HR：1.13，95%CI：1.02，1.25）、总体苏打水（HR：1.13，95%CI：1.00，1.26）和人工甜味苏打水（HR：1.13，95%CI：1.01，1.27）在第一个随访间隔。
苏打水摄入量的增加可能与肝癌风险相关。结果表明，减少非糖尿病患者的 SS 苏打水摄入和糖尿病患者的 AS 苏打水摄入可能与降低肝癌风险有关。
