血糖水平升高对听力损失的影响。
The effect of increase in blood glucose level on hearing loss.
机构信息
Hitit University, Faculty of Medicine, Department of Biophysics, Çorum, Turkey.
Atatürk University, Faculty of Medicine, Department of Biophysics, Erzurum, Turkey.
出版信息
Braz J Otorhinolaryngol. 2022 Nov-Dec;88 Suppl 3(Suppl 3):S95-S102. doi: 10.1016/j.bjorl.2022.06.003. Epub 2022 Jun 15.
OBJECTIVE
Previous studies have shown that hearing function is also vulnerable to the effects of diabetes mellitus which can be shown by brainstem auditory evoked potential and distortion product otoacoustic emission recordings. This study aimed to investigate the changes of brainstem auditory evoked potential and distortion product otoacoustic emission in hyperglycemia and whether there is a relationship between reactive oxygen substances production and hearing deterioration in the rat model.
METHODS
25 streptozotocin induced diabetic rats were divided into three groups: control, high blood glucose, and diabetes mellitus. Brainstem auditory evoked potential and distortion product otoacoustic emission were recorded, and thiobarbituric acid reactive substances levels were measured in the brainstem tissue.
RESULTS
At 8 kHz, the latencies of I, II, III, IV, and V brainstem auditory evoked potential waves in high blood glucose and diabetes mellitus groups were elongated, at 16 kHz, only these wave latencies of the diabetes mellitus group were prolonged compared with the control group. A significant decrease was also found in distortion product otoacoustic emission amplitudes at 4, 6, 8, and 10 kHz in the high blood glucose and diabetes mellitus groups compared to the control group. There was a significant increase in thiobarbituric acid reactive substances values due to the increase in blood glucose levels in the high blood glucose and diabetes mellitus groups compared to the control group.
CONCLUSION
These results suggested that high blood glucose levels may cause hearing impairment not only in the diabetic state but also in the period of hyperglycemia before the onset of manifest diabetes mellitus and reactive oxygen substances may play an important role in the pathophysiology of diabetes mellitus. We suggest that regulating high glucose levels even before the onset of manifest diabetes mellitus may prevent hazardous effects on hearing function.
LEVEL OF EVIDENCE
Level 3.
目的
先前的研究表明，听觉功能也容易受到糖尿病的影响，这可以通过脑干听觉诱发电位和畸变产物耳声发射记录来显示。本研究旨在探讨高血糖大鼠模型中脑干听觉诱发电位和畸变产物耳声发射的变化，以及活性氧物质的产生与听力下降之间是否存在关系。
方法
将 25 只链脲佐菌素诱导的糖尿病大鼠分为三组：对照组、高血糖组和糖尿病组。记录脑干听觉诱发电位和畸变产物耳声发射，并测量脑干组织中丙二醛反应物质的水平。
结果
在 8 kHz 时，高血糖组和糖尿病组的 I、II、III、IV 和 V 波的潜伏期延长，在 16 kHz 时，只有糖尿病组的这些波潜伏期较对照组延长。与对照组相比，高血糖组和糖尿病组在 4、6、8 和 10 kHz 时畸变产物耳声发射幅度也显著降低。与对照组相比，高血糖组和糖尿病组由于血糖升高，丙二醛反应物质值显著增加。
结论
这些结果表明，高血糖水平不仅在糖尿病状态下，而且在明显糖尿病发生前的高血糖期，都可能导致听力损伤，活性氧物质可能在糖尿病的病理生理学中起重要作用。我们建议，即使在明显糖尿病发生之前，调节高血糖水平也可能预防对听力功能的有害影响。
证据水平
3 级。
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