Sarais Fabio, Perdomo-Sabogal Alvaro, Wimmers Klaus, Ponsuksili Siriluck
Institute for Genome Biology, Research Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.
Faculty of Agricultural and Environmental Sciences, University Rostock, 18059 Rostock, Germany.
Noncoding RNA. 2022 May 26;8(3):37. doi: 10.3390/ncrna8030037.
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) belong to a group of transfer ribonucleic acid (tRNA)-derived fragments that have recently gained interest as molecules with specific biological functions. Their involvement in the regulation of physiological processes and pathological phenotypes suggests molecular roles similar to those of miRNAs. tsRNA biogenesis under specific physiological conditions will offer new perspectives in understanding diseases, and may provide new sources for biological marker design to determine and monitor the health status of farm animals. In this review, we focus on the latest discoveries about tsRNAs and give special attention to molecules initially thought to be mainly associated with tRNA-derived stress-induced RNAs (tiRNAs). We present an outline of their biological functions, offer a collection of useful databases, and discuss future research perspectives and applications in livestock basic and applied research.
转运RNA（tRNA）衍生的小RNA（tsRNA）属于一组转运核糖核酸（tRNA）衍生片段，作为具有特定生物学功能的分子，它们最近受到了关注。它们参与生理过程和病理表型的调节，表明其分子作用类似于微小RNA（miRNA）。特定生理条件下的tsRNA生物合成将为理解疾病提供新的视角，并可能为确定和监测农场动物健康状况的生物标志物设计提供新来源。在本综述中，我们重点关注tsRNA的最新发现，并特别关注最初被认为主要与tRNA衍生的应激诱导RNA（tiRNA）相关的分子。我们概述了它们的生物学功能，提供了有用数据库的汇总，并讨论了在畜牧基础研究和应用研究中的未来研究前景及应用。
