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直肠前切除术后 30 天内,预防性造口术可降低吻合口漏的再次手术率,但不能降低总体再次手术率:一项全国性队列研究。

Diverting stomas reduce reoperation rates for anastomotic leak but not overall reoperation rates within 30 days after anterior rectal resection: a national cohort study.

机构信息

Department of Gastrointestinal Surgery, University Hospital of North Norway, 9019, Tromsø, Norway.

Institute of Clinical Medicine, Faculty of Health Science, UiT, The Arctic University of Norway, 9019, Tromsø, Norway.

出版信息

Int J Colorectal Dis. 2022 Jul;37(7):1681-1688. doi: 10.1007/s00384-022-04205-8. Epub 2022 Jun 24.

Abstract

PURPOSE

A diverting stoma is commonly formed to reduce the rate of anastomotic leak following anterior resection with anastomosis, although some studies question this strategy. The aim of this study was to assess the leak rates and overall complication burden after anterior resection with and without a diverting stoma.

METHODS

A 5-year national cohort with prospectively registered data of patients who underwent elective anterior resection for rectal cancer located < 15 cm from the anal verge. Data were retrieved from the Norwegian Registry for Gastrointestinal Surgery and the Norwegian Colorectal Cancer Registry. Primary end point was relaparotomy or relaparoscopy for anastomotic leak within 30 days from index surgery. Secondary endpoints were postoperative complications including reoperation for any cause.

RESULTS

Some 1018 patients were included of whom 567 had a diverting stoma and 451 had not. Rate of reoperation for anastomotic leak was 13 out of 567 (2.3%) for patients with diverting stoma and 35 out of 451 (7.8%) (p > 0.001) for patients without. In multivariable analyses not having a diverting stoma (aOR 3.77, c.i 1.97-7.24, p < 0.001) was associated with increased risk for anastomotic leak. However, there were no differences in overall reoperation rates following anterior resection with or without diverting stoma (9.3% vs 10.9%, p = 0.423), and overall complication rates were similar. Reoperation was associated with increased mortality irrespective of the main intraoperative finding.

CONCLUSION

Diverting stoma formation after anterior resection is protective against reoperation for anastomotic leak but does not affect overall rates of reoperation or complications within 30 days.

摘要

目的

在进行吻合的前切除术之后,通常会形成一个转流造口以降低吻合口漏的发生率,尽管一些研究对这种策略提出了质疑。本研究的目的是评估在进行前切除术时是否形成转流造口对吻合口漏的发生率和总体并发症负担的影响。

方法

本研究为一项前瞻性注册的全国性队列研究,纳入了 5 年内接受择期前切除术治疗距肛缘<15cm 的直肠肿瘤的患者。数据来源于挪威胃肠外科登记处和挪威结直肠癌登记处。主要终点是指数手术后 30 天内再次剖腹手术或腹腔镜检查吻合口漏。次要终点是包括任何原因的再次手术在内的术后并发症。

结果

共纳入 1018 例患者,其中 567 例患者行转流造口术,451 例患者未行转流造口术。行转流造口术的患者中,吻合口漏的再手术率为 13/567(2.3%),而行非转流造口术的患者为 35/451(7.8%)(p>0.001)。多变量分析显示,未行转流造口术(aOR 3.77,95%CI 1.97-7.24,p<0.001)与吻合口漏的风险增加相关。然而,在行或不行转流造口术的前切除术患者中,总体再手术率无差异(9.3% vs 10.9%,p=0.423),且总体并发症发生率相似。无论主要术中发现如何,再次手术都与死亡率增加相关。

结论

在前切除术之后形成转流造口可以预防因吻合口漏而再次手术,但不会影响 30 天内的总体再手术率或并发症发生率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ab5/9262798/b8e34c30fd53/384_2022_4205_Fig1_HTML.jpg

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