Fiorentino Julie, Payne Magali, Cancian Elisa, Plonka Alexandra, Dumas Louise-Émilie, Chirio David, Demonchy Élisa, Risso Karine, Askenazy-Gittard Florence, Guevara Nicolas, Castillo Laurent, Robert Philippe, Manera Valeria, Vandersteen Clair, Gros Auriane
Département d'Orthophonie de Nice, Faculté de Médecine de Nice, 06107 Nice, France.
Laboratoire CoBTeK, Institut Claude Pompidou, Université Côte d'Azur, 06100 Nice, France.
Brain Sci. 2022 May 31;12(6):714. doi: 10.3390/brainsci12060714.
: One of the main symptoms of COVID-19 is hyposmia or even anosmia. Olfactory identification is most often affected. In addition, some cognitive disorders tend to appear following the infection, particularly regarding executive functions, attention, and memory. Olfaction, and especially olfactory identification, is related to semantic memory which manages general knowledge about the world. The main objective of this study was to determine whether semantic memory is impaired in case of persistent post COVID-19 olfactory disorders. : 84 patients (average age of 42.8 ± 13.6 years) with post COVID-19 olfactory loss were included after consulting to the ENT department. The clinical evaluation was carried out with the Pyramid and Palm Tree Test, the word-retrieval task from the Grémots, the Sniffin' Sticks Test and the Computerised Olfactory Test for the Diagnosis of Alzheimer's Disease. : Semantic memory was impaired in 20% ( = 17) of patients, especially in the 19-39 age-group. The olfactory threshold was only significantly correlated with the semantic memory scores. : Similar to all cognitive disorders, semantic disorders can have a negative impact on quality of life if left untreated. It is essential to carry out specific assessments of post COVID-19 patients to accurately determine their disorders and to put in place the best possible rehabilitation, such as speech and language therapy, to avoid quality-of-life impairment.
新冠病毒病（COVID-19）的主要症状之一是嗅觉减退甚至嗅觉丧失。嗅觉识别往往受到的影响最大。此外，感染后往往会出现一些认知障碍，尤其是在执行功能、注意力和记忆方面。嗅觉，尤其是嗅觉识别，与管理关于世界的一般知识的语义记忆有关。本研究的主要目的是确定在新冠病毒病后持续性嗅觉障碍的情况下语义记忆是否受损。：84名新冠病毒病后嗅觉丧失的患者（平均年龄42.8±13.6岁）在咨询耳鼻喉科后被纳入研究。临床评估采用金字塔和棕榈树测试、法语词汇检索任务、嗅觉棒测试以及用于阿尔茨海默病诊断的计算机嗅觉测试。：20%（=17）的患者存在语义记忆受损，尤其是在19 - 39岁年龄组。嗅觉阈值仅与语义记忆得分显著相关。：与所有认知障碍一样，如果不治疗，语义障碍会对生活质量产生负面影响。对新冠病毒病后患者进行特定评估以准确确定他们的障碍并实施最佳康复措施（如言语和语言治疗）以避免生活质量受损至关重要。
