Drelich-Zbroja Anna, Matuszek Małgorzata, Kaczor Michał, Kuczyńska Maryla
Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, Poland.
Student's Scientific Society at the Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, 20-059 Lublin, Poland.
J Clin Med. 2022 Jun 20;11(12):3561. doi: 10.3390/jcm11123561.
Obesity remains a pandemic of the 21st century. While there are many causes of obesity and potential treatments that are currently known, source data indicate that the number of patients is constantly increasing. Neural mechanisms have become the subject of research and there has been an introduction of functional magnetic resonance imaging in obesity-associated altered neural signaling. Functional magnetic resonance imaging has been established as the gold standard in the assessment of neuronal functions related to nutrition. Thanks to this, it has become possible to delineate those regions of the brain that show altered activity in obese individuals. An integrative review of the literature was conducted using the keywords ""functional neuroimaging" OR "functional magnetic resonance "OR "fmri" and "obesity" and "reward circuit and obesity" in PubMed and Google Scholar databases from 2017 through May 2022. Results in English and using functional magnetic resonance imaging to evaluate brain response to diet and food images were identified. The results from functional magnetic resonance imaging may help to identify relationships between neuronal mechanisms and causes of obesity. Furthermore, they may provide a substrate for etiology-based treatment and provide new opportunities for the development of obesity pharmacotherapy.
肥胖仍然是21世纪的一种流行病。虽然目前已知肥胖有多种成因和潜在治疗方法,但源数据表明患者数量在不断增加。神经机制已成为研究对象,功能磁共振成像已被引入肥胖相关的神经信号改变研究中。功能磁共振成像已被确立为评估与营养相关的神经元功能的金标准。借助于此,已能够描绘出肥胖个体中显示活动改变的大脑区域。使用关键词“功能神经成像”或“功能磁共振”或“fMRI”以及“肥胖”和“奖赏回路与肥胖”,于2017年至2022年5月在PubMed和谷歌学术数据库中对文献进行了综合综述。识别出了使用功能磁共振成像评估大脑对饮食和食物图像反应的英文结果。功能磁共振成像的结果可能有助于确定神经元机制与肥胖成因之间的关系。此外,它们可能为基于病因的治疗提供基础,并为肥胖药物治疗的发展提供新机会。