Ma Kirsten F, Kleiss Simone F, Schuurmann Richte C L, Nijboer Thomas S, El Moumni Mostafa, Bokkers Reinoud P H, de Vries Jean-Paul P M
Division of Vascular Surgery, Department of Surgery, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Division of Trauma Surgery, Department of Surgery, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
J Pers Med. 2022 May 24;12(6):853. doi: 10.3390/jpm12060853.
In this study, we assessed the ability of the EPOS system (Perimed AB, Järfälla, Stockholm, Sweden) to detect differences in tissue perfusion between healthy volunteers and patients with peripheral arterial disease (PAD) with different severity of disease.
This single-center prospective pilot study included 10 healthy volunteers and 20 patients with PAD scheduled for endovascular therapy (EVT). EPOS measurements were performed at rest at 32 °C and 44 °C, followed by transcutaneous oxygen pressure (TcPo) measurements. The measurements were performed on the dorsal and medial side of the foot, as well as the lateral side of the calf. EPOS parameters included hemoglobin oxygen saturation (HbSo) and speed-resolved red blood cell (RBC) perfusion.
HbSo at 44 °C was significantly different between the three groups for all measurement locations. The overall speed-resolved RBC perfusion at 44 °C was statistically significant between the groups on the dorsal and medial side of the foot but not on the calf. TcPo values were not significantly different between the three groups.
This study demonstrates that the EPOS system can depict differences in tissue perfusion between healthy volunteers, patients with Fontaine class IIb PAD, and those with Fontaine class III or IV PAD but only after heating to 44 °C.
在本研究中，我们评估了EPOS系统（瑞典斯德哥尔摩耶夫勒的Perimed AB公司）检测健康志愿者与不同疾病严重程度的外周动脉疾病（PAD）患者之间组织灌注差异的能力。
这项单中心前瞻性试点研究纳入了10名健康志愿者和20名计划接受血管内治疗（EVT）的PAD患者。在32°C和44°C静息状态下进行EPOS测量，随后进行经皮氧分压（TcPo）测量。测量在足部的背侧和内侧以及小腿外侧进行。EPOS参数包括血红蛋白氧饱和度（HbSo）和速度分辨红细胞（RBC）灌注。
在所有测量部位，三组之间44°C时的HbSo存在显著差异。足部背侧和内侧组间44°C时的总体速度分辨RBC灌注具有统计学意义，而小腿部位则无。三组之间的TcPo值无显著差异。
本研究表明，EPOS系统能够描绘健康志愿者、Fontaine IIb级PAD患者以及Fontaine III或IV级PAD患者之间的组织灌注差异，但仅在加热至44°C后。
