Surgical Diseases Department, Karaganda Medical University, 40 Gogol str., Karaganda 100000, Kazakhstan.
Stem Cells Laboratory, National Center for Biotechnology, 13/5 Korgalzhyn Ave., Nur-Sultan 01000, Kazakhstan.
Medicina (Kaunas). 2022 Jun 17;58(6):819. doi: 10.3390/medicina58060819.
Homogeneous and xenogenic bioengineering structures are actively used as wound coatings in treatment of burns and have already shown their effectiveness. Nevertheless, the disadvantage of such dressings is their high cost. This issue is particularly challenging for developing countries in which the incidence of burns is the highest one. With such needs taken into account, the research team developed and clinically tested a new wound coating based on decellularized bovine peritoneum (DBP). A multicenter randomized clinical trial was conducted to evaluate DBP. The following variables were considered in the research study: the number of inpatient days, the number of dressing changes, the level of pain experienced during dressing changes, and the condition of wounds at the time of the follow-up examination. The research involved 68 participants. It was found that the patients who were treated with a DBP experienced less pain with less changes of dressings. However, the number of inpatient days and wound healing failed to demonstrate statistically significant difference compared to the control group. In the given research, DBP showed efficacy in improving patients' quality of life by reducing pain and the number of dressings' changes. However, when comparing this research study with the studies of other animal-derived wound coverings, there were a number of differences and limitations in the parameters. Thus, the results requires further study for a greater comparability of data. Given the above, we expect that DBP will become an inexpensive and effective treatment for burns in developing countries.
同种异体和异种生物工程结构被积极用作烧伤治疗的伤口涂层，已经显示出其有效性。然而，这种敷料的缺点是成本高。对于烧伤发病率最高的发展中国家来说，这个问题尤其具有挑战性。考虑到这些需求，研究团队开发并临床测试了一种基于去细胞牛腹膜（DBP）的新型伤口涂层。进行了一项多中心随机临床试验来评估 DBP。在研究中考虑了以下变量：住院天数、敷料更换次数、敷料更换过程中的疼痛程度以及随访检查时伤口的状况。该研究涉及 68 名参与者。结果发现，接受 DBP 治疗的患者在敷料更换次数较少的情况下疼痛较轻。然而，与对照组相比，住院天数和伤口愈合没有显示出统计学上的显著差异。在这项研究中，DBP 通过减少疼痛和敷料更换次数来提高患者的生活质量，显示出疗效。然而，当将这项研究与其他动物源性伤口覆盖物的研究进行比较时，在参数方面存在一些差异和局限性。因此，结果需要进一步研究以提高数据的可比性。鉴于上述情况，我们预计 DBP 将成为发展中国家治疗烧伤的一种廉价且有效的方法。
