多囊卵巢综合征患者循环网膜素-1 水平与炎症反应。
Circulating omentin-1 levels and inflammation in polycystic ovary syndrome.
机构信息
Department of Endocrinological Gynecology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice.
Women's Health Chair, School of Health Science, Medical University of Silesia, Poland.
出版信息
Ginekol Pol. 2020;91(6):308-312. doi: 10.5603/GP.2020.0057.
OBJECTIVES
The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and inflammation in PCOS.
MATERIAL AND METHODS
A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and sR-IL6 were measured in the fasting state.
RESULTS
Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin- 1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.
CONCLUSIONS
Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines are factors modifying secretion of this adipokine.
目的
本研究旨在分析多囊卵巢综合征（PCOS）患者血浆网膜素-1 水平与营养状况和炎症之间的关系。
材料与方法
本横断面研究纳入了 86 例 PCOS（47 例肥胖）和 72 例非 PCOS 妇女（41 例肥胖），测定了人体测量学参数和身体成分。空腹状态下检测血清葡萄糖、胰岛素和网膜素-1、TNF-α、sTNFRs、IL-6 和 sR-IL6。
结果
与非 PCOS 组和相应的正常体重和肥胖亚组相比，PCOS 患者的血浆网膜素-1 水平显著降低。在三个分析的最小角回归（LARS）模型中，较低的血浆网膜素-1 水平与 PCOS 的发生有关，与较高的循环 TNF-α和较低的 IL-6 水平有关。
结论
PCOS 患者的网膜素-1 水平降低是这种紊乱的特征，促炎细胞因子是调节这种脂肪因子分泌的因素。
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