Department of Endocrinological Gynecology, Faculty of Medicine in Katowice, Medical University of Silesia, Katowice.
Women's Health Chair, School of Health Science, Medical University of Silesia, Poland.
Ginekol Pol. 2020;91(6):308-312. doi: 10.5603/GP.2020.0057.
The aim of the study was to analyze interrelation between plasma omentin-1 levels and nutritional status and inflammation in PCOS.
A cross-sectional study involving 86 PCOS (47 obese) and 72 Non-PCOS women (41 obese) determined anthropometric parameters and body composition. Serum glucose, insulin and omentin-1, TNF-α, sTNFRs, IL-6 and sR-IL6 were measured in the fasting state.
Plasma omentin-1 levels were significantly lower in the PCOS than in the Non-PCOS group and both corresponding normal weight and obese subgroups. In three analyzed least-angle regression (LARS) models the lower plasma omentin- 1 levels was associated with PCOS occurrence, higher circulating TNF-α and lower IL-6 levels.
Suppressed omentin-1 levels in PCOS are characteristic for this disturbance and proinflammatory cytokines are factors modifying secretion of this adipokine.
本研究旨在分析多囊卵巢综合征（PCOS）患者血浆网膜素-1 水平与营养状况和炎症之间的关系。
本横断面研究纳入了 86 例 PCOS（47 例肥胖）和 72 例非 PCOS 妇女（41 例肥胖），测定了人体测量学参数和身体成分。空腹状态下检测血清葡萄糖、胰岛素和网膜素-1、TNF-α、sTNFRs、IL-6 和 sR-IL6。
与非 PCOS 组和相应的正常体重和肥胖亚组相比，PCOS 患者的血浆网膜素-1 水平显著降低。在三个分析的最小角回归（LARS）模型中，较低的血浆网膜素-1 水平与 PCOS 的发生有关，与较高的循环 TNF-α和较低的 IL-6 水平有关。
PCOS 患者的网膜素-1 水平降低是这种紊乱的特征，促炎细胞因子是调节这种脂肪因子分泌的因素。
